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Molecular therapy for Metastatic cancers: Torasemide, an anti-hypertensive drug, increases the expression of tumor/metastasis suppressors CCM3/KRIT1 and TIMP3, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 8/January/2017, 10.48 pm

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From Significance of the study to Public health relevance:

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

This study suggests, for the first time, that  Torasemide, by regulating the expression of its target genes, it may increase the expression of tumor suppressors  CCM3/KRIT1 and TIMP3 (fig. 1).

 

Thereby, it may: (a) inhibit cell cycle progression; and (d) suppress migration, invasion and metastasis of cancer cells.   [easy_payment currency=”USD”]

Thus,  Torasemide-based treatment may be advised for metastatic cancer patients to (i) increase the expression of metastasis suppressor genes in tumors; (ii) inhibit the progression of metastatic tumors; and (ii) enhance the efficacy of Cancer therapy. Together, this study suggests that oncologists may consider experimenting Torasemide in the treatment of advanced metastatic cancers.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $10#

Undisclosed mechanistic information: How Torasemide increases the expression of  tumor/metastasis suppressors CCM3/KRIT1 and TIMP3

Fig1. Mechanistic insights into how the anti-hypertensive medication Torasemide functions as an anti-metastasis agent. Torasemide increases the expression of tumor suppressors CCM3/KRIT1 and TIMP3 via up regulation of its target genes.

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References: 

CitationBoominathan, L., Molecular therapy for Metastatic cancers: Torasemide, an anti-hypertensive drug, increases the expression of tumor/metastasis suppressors CCM3/KRIT1 and TIMP3, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 8/January/2017, 10.48 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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