January

January 15, 2018

Molecular therapy for body weight control, energy homeostasis and TIIDM: Fluoxetine[Trade name: Prozac and Sarafem], an antidepressant,  increases REV-ERB and its down stream target genes, inhibits lipid accumulation, improves dyslipidemia and insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 16/January/2018, 4.55 am

Introduction: What they say A study from the Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, Florida 33458, USA shows that “Regulation of circadian behaviour […]
January 15, 2018

Activation of the PD-1 pathway for Pain therapy: Melatonin[N-acetyl-5-methoxy tryptamine], a hormone that regulates sleep and wakefulness,  increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 16/January/2017, 4.35 am

Introduction:What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
January 14, 2018

 Natural product-derived therapy for blood-stage Plasmodium infection: Berberine, isolated from Berberis among others, decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 15/January/2018, 5.17 am

Introduction: What they say A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that […]
January 14, 2018

Natural product-based therapy for Diabetic retinopathy: A pharmaceutical mixture encompassing Fluvastatin, Epicatechin and Matrine (ANEM) inhibits Soluble epoxide hydrolase (sEH) expression, decreases toxic 19,20-dihydroxydocosapentaenoic acid levels, inhibits pericyte loss, vascular permeability, and inflammation of the eye and progression of diabetic retinopathy, via down regulation of its target gene, 15/January/2018, 5.07 am

Introduction: What they say A study from the Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, Germany; and German Centre for […]