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Branched-chain amino acids-based Lifespan extension therapy:  Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase life span via up-regulation of its target gene BubR1, 27/February/2018, 1.23 pm

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 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the journal  “EMBO”, by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Branched-chain amino acids-based Lifespan extension therapy:  Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase life span via up-regulation of its target gene BubR1


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, that Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine)by increasing the expression of their target genes, they may: (a) increase the expression of BuBR1; (b) regulate the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).

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Figure 1. Branched-chain amino acids (BCAA) may extend  mammalian life span via up regulation of BuBR1

Figure 2. The chemical structure of Branched-chain amino acids (BCAA). BCAA functions as a longevity-promoter through induction of BuBR1.

Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, pharmacological formulations encompassing “branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine)  or their analogues, either alone or in combination with other drugs, may be used to extend the lifespan of an individual (fig. 2).


Details on the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $500#

Undisclosed mechanistic information: How a pharmaceutical mix encompassing  Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase the expression of BubR1 and extend mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L.,  Branched-chain amino acids-based Lifespan extension therapy:  Branched-chain amino acids (BCAA-Leucine, Isoleucine and Valine) increase life span via up-regulation of its target gene BubR1, 27/February/2018, 1.23 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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