What they say:
A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March 2013 issue of of the jounal Nature, by Prof Dimmler, Boon, and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Combinatorial therapy for Myocardial Infarction: A pharmaceutical mixture encompassing Pyridoxamine (PM, Vit-B6) and Lansoprazole (LP) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up regulation of PNUTS
From Significance of the study to Public Health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.
From Research Findings to Therapeutic Opportunity:
This study provides provides, for the first time, mechanistic insight into how a pharmaceutical mixture encompassing Pyridoxamine (PM, Vitamin-B6) and D-3-Hydroxybutyrate may protect against myocardial infarction. D-3-Hydroxybutyrate is a ketone body and its level is increased upon starvation. It has recently been shown to it extend lifespan. However, the mechanism of action is far from clear.
A pharmaceutical mixture encompassing Pyridoxamine (PM, Vit-B6) and D-3-Hydroxybutyrate , by increasing the expression of its target genes, it may increase the expression of PNUTS (fig.1) . Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration; (5) decelerate ageing; and (6) extend life span (fig 1).
Thus, by treating patients with PMLP, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests that pharmacological formulations encompassing “Pyridoxamine (PM, Vit-B6) and D-3-Hydroxybutyrate or their analogs, either alone or in combination with any of the known compounds that improve myocardial function” may be used to improve cardiac function after myocardial infarction (fig. 3).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How a pharmaceutical mixture encompassing Pyridoxamine (PM, Vit-B6) and D-3-Hydroxybutyrate increases the expression of PNUTS/Telomerase
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Citation: Boominathan, L., Combinatorial therapy for Myocardial Infarction: A pharmaceutical mixture encompassing Pyridoxamine (PM, Vit-B6) and D-3-Hydroxybutyrate inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction via up regulation of PNUTS, 14/February/2018, 11.06 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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