Life-extension therapy: D-Glucosamine(GlcN) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 8/February/2018, 10.33 pm

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What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that:  Life-extension therapy: D-Glucosamine(GlcN) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span



Research findings to Therapeutic opportunity: 

Figure 1. Mechanistic insight into how D-Glucosamine may extend lifespan.  D-Glucosamine inhibits p70 S6 kInase expression and promotes longevity

Figure 2. The chemical structure of D-Glucosamine

D-Glucosamine, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

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Thus, pharmacological formulations encompassing “D-Glucosamine  or its analogs, either alone or in combination with any of the known longevity-promoting compound(s)” may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How D-Glucosamine decreases the expression of p70 S6 Kinase and promote mammalian life span

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References:

CitationBoominathan, L., Life-extension therapy: D-Glucosamine(GlcN) inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 8/February/2018, 10.33 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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