Dr L Boominathan PhD
President, Director & CSO, GBMD.
What they say:
A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November 2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054], by Prof. Thistlethwaite PA, Li X and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Molecular therapy for pulmonary arterial hypertension: Melatonin inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3
Significance of the study:
This study suggests, for the first time, that Spermidine, by increasing the expression of its target gene, it may decrease, in dose-dependent manner, the expression of Notch3 and its target gene Hes-5 (Fig.1). Thereby, it may inhibit and promote, respectively, proliferation and differentiation of smooth muscle cells. And, thereby, prevent pulmonary hypertension (Figure 1). Thus, pharmacological formulations encompassing “Spermidine or its analogues, either alone or in combination with other drugs,“ may be used to treat pulmonary arterial hypertension (Figure 2). Together, this study suggests that, by treating pulmonary hypertensive patients with Spermidine, one may prevent pulmonary arterial hypertension.
Details of the research findings:
Idea Proposed/Formulated by:
Dr L Boominathan Ph.D.
Undisclosed mechanistic information: How Spermidine decreases the expression of Notch3 and its target gene
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Citation: Boominathan, L., Molecular therapy for pulmonary arterial hypertension: Spermidine, an endogenous polyamine, inhibits the development of pulmonary arterial hypertension via down regulation of its target gene Notch3, 28/February/2018, 10.56 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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