Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing  L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 24/February/2017, 6.42 am

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Introduction: What they say

A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”,  by Prof. Jung YK, Pyo Jo and others.

Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of of ATG5 in the regulation of autophagy.


What we say: 

On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing  L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5)


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that a therapeutic mix encompassing  L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) , by increasing the expression of its target genes, it may increase the expression of ATG5. Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features (Fig.1).

Figure1. A therapeutic mix L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) functions as a longevity promoting agent. The therapeutic mix SCCMUDIL increases ATG5 expression and promotes leanness, insulin sensitivity, motor function and longevity.

Figure 2. L-Arginine, in conjunction with other compounds (LACCMUDIL), may function as a longevity-promoting agent through induction of ATG5.

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Thus, pharmacological formulations encompassing  L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) or their  analogues, either alone or in combination with drugs” may be used to increase the lifespan of an individual (Fig.1).


Details of the research findings: 

Idea Proposed/Formulated by: Dr L Boominathan PhD

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# Research cooperation

Undisclosed mechanistic information: How does a therapeutic mix encompassing L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) increase the expression of ATG5 and promote longevity?


References: 

Web: http://genomediscovery.org or newbioideas.com/

To cite: Boominathan, L., Natural product-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing  L-Arginine, Catalpol, Cholecalciferol, Maresin, Ursolic acid, DIM, Isoliquiritigenin, & Lutein   (LACCMUDIL) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 24/February/2017, 6.42 am

Courtesy: When you cite us, just drop us a line at info@genomediscovery.org

 

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