A sweet way to extend lifespan: Sugar-based Life-extension therapy: D-Allose, an aldohexose sugar,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span by regulating the expression of its target genes, 13/March/2017, 11.34 pm

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What they say:

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ),  by Prof. Dominic J. Withers, Dr. Selman C and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: A sweet way to extend lifespan: Sugar-based Life-extension therapy: D-Allose, an aldohexose sugar,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span by regulating the expression of its target genes


Research findings to Therapeutic opportunity: 

This study suggests, for the first time, a sugar-based Life-extension therapy. 

Figure 1. Mechanistic insight into how D-Allose may extend lifespan.  D-Allose may promote longevity by suppressing the expression of p70 S6 kInase; and by regulating the expression of a number of other genes.

Figure 2. D-Allose functions as a longevity-promoter through down regulation of p70S6 Kinase.

 D-Allose, by  regulating  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).

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Thus, pharmacological formulations encompassing “D-Allose or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),” may be used to extend the lifespan of an individual (fig. 2).

 


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How D-Allose decreases the expression of p70 S6 Kinase and promotes mammalian life span

# Research cooperation

Amount: $500#

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References:

CitationBoominathan, L.,    A sweet way to extend lifespan: Sugar-based Life-extension therapy: D-Allose, an aldohexose sugar,  inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span by regulating the expression of its target genes, 13/March/2017, 11.34 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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