Site is Being Upgraded

A sweet way to extend lifespan: Sugar-based Lifespan extension therapy: D-Allulose/D-Psicose, a low-calorie sweetener isolated from natural products, may increase life span via up-regulation of its target gene BubR1, 16/March/2018, 6.50 am

Natural product-based therapy for Regenerating the lost pancreatic β-cells in Diabetic patients: Hesperidin, isolated from citrus aurantium, increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state via up-regulation of  its target gene Lin28, 16/March/2018, 6.38 am
March 16, 2018
A sweet way to say no to Autoimmune diabetes (TIDM): Sugar-based therapy for autoimmune diabetes (TIDM): Trehalose, a natural sweetener isolated from mushrooms among others,  increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 16/March/2018, 7.20 am
March 16, 2018
Show all

 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the journal  “EMBO”, by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A sweet way to extend lifespan: Sugar-based Lifespan extension therapy: D-Allulose/D-Psicose, a low-calorie sweetener isolated from natural products, may increase life span via up-regulation of its target gene BubR1


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, that D-Allulose/D-Psicoseby increasing the expression of its target gene, it may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (Fig. 1).

[easy_payment currency=”USD”]

Figure 1.  D-Allulose/D-Psicose may extend  mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase

Figure 2. The chemical structure of D-Allulose/D-Psicose.  D-Allulose/D-Psicose functions as a longevity-promoter through induction of BuBR1.

Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, pharmacological formulations encompassing “D-Allulose/D-Psicose  or its analogues, either alone or in combination with other drugs, may be used to extend the lifespan of an individual (fig. 2).


Details on the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $500#

Undisclosed mechanistic information: How D-Allulose/D-Psicose increases the expression of BubR1 and extends mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., A sweet way to extend lifespan: Sugar-based Lifespan extension therapy: D-Allulose/D-Psicose, a low-calorie sweetener isolated from natural products, may increase life span via up-regulation of its target gene BubR1, 16/March/2018, 6.50 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at admin@genomediscovery.org

Comments are closed.