Site is Being Upgraded

Hydrogen gas therapy for body weight control, energy homeostasis and TIIDM: Hydrogen gas inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 29/March/2018, 6.19 am

A noble way to say no to cardiac diseases: Noble gas Xenon-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Inhalation of noble gas Xenon decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 29/March/2018, 5.50 am
March 29, 2018
A noble way to keep cardiac diseases at bay: Noble gas xenon-based cardiac rejuvenation therapy: Inhalation of Xenon gas suppresses tumor suppressor INK4a/p16 expression, and inhibits dilated cardiomyopathy via up regulation of its target gene, 29/March/2018, 6.31 am
March 29, 2018
Show all

Introduction: What they say 

A study from Nutritional Sciences and Toxicology Department, University of California, Berkeley, Berkeley, United States shows that “Dnmt3a is an epigenetic mediator of adipose insulin resistance.” This research paper was published, in the 1 Nov 2017 issue of the journal “Elife”, by Prof.Kang S, You D and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Hydrogen gas therapy for body weight control, energy homeostasis and TIIDM: Hydrogen gas inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene


From significance of the study to public health relevance:

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

Prof.Kang’s research team has recently shown that:(1) DNA methyltransferase 3a (Dnmt3a) promotes insulin resistance; (2) DNMT3a null mice are resistant to diet-induced insulin resistance and glucose intolerance; (3) FGF21 is a negative target of DNMT3a gene and its promoter region is heavily methylated in patients with diabetes; and (4) FGF21 induction attenuates Dnmt3a-mediated insulin resistance, suggesting that decreasing the expression of DNMT3a may result in (a) induction of FGF21; (b) increased insulin sensitivity and glucose tolerance; and (3) attenuation of Obesity-associated TIIDM.


From research findings to Therapeutic opportunity:

This study suggests a hydrogen gas-based therapy for Obesity-associated TIIDM.  Hydrogen gas, by increasing the expression of its target gene, it may decrease the expression of DNMT3a. Thereby, it may: (1) decrease methylation at the FGF21 promoter region; (2) increase FGF21 expression; (3) augment insulin sensitivity; (4) increase glucose tolerance; and (5) inhibit diet-induced insulin resistance (Fig.1). Thus, “hydrogen gas, either alone or in combination with other gases,” may be used to treat Obesity-associated TIIDM (Fig.2).

Figure 1. Mechanistic insights into Hydrogen gas attenuates insulin resistance and cardiac ageing. Hydrogen gas, by inhibiting DNMT3a expression, induces FGF21 expression, promotes regeneration, attenuates insulin resistance and cardiac ageing and promotes longevity

Figure 2. Hydrogen gas attenuates weight gain, insulin resistance, diabetic cardiomyopathy, myocardial infarction and cardiac ageing through induction of FGF21


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Hydrogen gas decrease the expression of DNMT3a to promote insulin sensitivity?

Amount: $500#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Hydrogen gas therapy for body weight control, energy homeostasis and TIIDM: Hydrogen gas inhibits DNA methyltransferase 3a (Dnmt3a) expression, increases FGF21 expression, augments insulin sensitivity, increases glucose tolerance, and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 29/March/2018, 6.19 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at info@genomediscovery.org

Comments are closed.