Sugar-based therapy for diabetes (TIIDM): D-Fagomine, an iminosugar isolated from mulberry leaves, among others, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 24/March/2018, 12.55 am
Introduction: What they say A study from the Comprehensive Diabetes Center and Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Alabama at Birmingham, Birmingham, AL shows that “miR-204 Controls Glucagon-Like Peptide 1 Receptor Expression and Agonist Function.” This research paper was published, in the 3 November 2017 issue of the journal “Diabetes” […]
A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy: Lactulose (brand name: Cholac, Generlac, Consulose, Duphalac) , a non-absorbable sugar that aids in the treatment of constipation and hepatic encephalopathy, prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 24/March/2018, 12.41 am
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Lactulose, by increasing the expression of […]
Molecular therapy for Non-alcoholic fatty liver disease (NAFLD): Melatonin promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD via down regulation of its target gene, 24/March/2018, 12.32 am
Significance of the study: Given that: (1) 15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD; and (4) the global economic cost […]
A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy: Xylitol, a sugar alcohol and artificial sweetener found in drugs, confections, toothpaste, and chewing gum, prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 23/March/2018, 12.25 am
Significance of the study: It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. From research findings to therapeutic opportunity: This study suggests, for the first time, that Xylitol, by increasing the expression of […]
A glass of milk a day keeps stroke at bay: Milk product-based therapy for Stroke: Rumenic acid, a conjugated linoleic acid found abundantly in Cow’s milk, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up regulation of its target genes BDNF and NAMPT, 23/March/2018, 12.14 am
Introduction: What they say A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke.“ This study was published, in the July 2 […]
Milk product-based Life-extension therapy: Lactoferrin, a globular protein found abundantly in biological fluids, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span by regulating the expression of its target genes, 23/March/2017, 12.04 am
What they say: A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof. Dominic J. Withers, Dr. Selman C and others. What […]
