Polyamine-based Lifespan extension therapy: Spermidine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 4/March/2018, 12.17 pm

Amino acid-based therapy for TIIDM and obesity-associated metabolic deficits: Glycine, a non-essential amino acid and inhibitory neurotransmitter,  increases Lipocalin 2 (LCN2) expression, activates an MC4R-dependent anorexigenic pathway, suppresses appetite and weight gain, increases insulin secretion, improves glucose tolerance, promotes glucose homeostasis, improves obesity-associated metabolic deficits and prevents progression to TIIDM via down regulation of its target gene, 4/March/2018, 11.45 am
March 4, 2018
Amino acid-based therapy for diabetes (TIDM): Glycine, a non-essential amino acid and inhibitory neurotransmitter, increases GLP1R and Caveolin-1 (CAV-1) expression, promotes glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM via up regulation of its target gene, 4/March/2018, 12.23 pm
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Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 

From research findings to therapeutic opportunity: 

This study suggests, for the first time, that Spermidine, by increasing the expression of its target genes,  it may decrease the expression of AT1R.

Figure1. Mechanistic insights into how Spermidine functions as a longevity-promoter. Spermidine, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity

Figure 2. The chemical structure of Spermidine.

And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Spermidine or its analogues or Berberine in combination with other anti-ageing/longevity promoting compounds may be used to extend the lifespan of an individual (Figures 1-2).

Price 300[easy_payment currency=”USD”]

Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does Spermidine suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $300

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


CitationBoominathan, L.,Polyamine-based Lifespan extension therapy: Spermidine prolongs mammalian life span via down regulation of angiotensin II type I receptor (AT1R), 4/March/2018, 12.17 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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