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A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy:  D-Allose, a C-3 epimer of glucose,  prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 4/April/2018, 12.19 pm

Alternative sweetener-based Lifespan extension therapy: Fructooligosaccharide, an alternative sweetener 30-50% as sweet as sugar,   increases life span via up-regulation of its target gene BubR1, 2/April/2017, 12.05 pm
April 2, 2018
Treating pain with sweet: Sugar-based activation of the PD-1 pathway for Pain therapy: D-Mannose, a C-2 epimer of glucose commonly used in the treatment of urinary tract infections, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 2/April/2018, 12.31 pm
April 2, 2018
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Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that  D-Allose, by increasing the expression of its target genes,  it may decrease the expression of AT1R.

Figure1. Mechanistic insights into how  D-Allose functions as a longevity-promoter. D-Allose, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity

Figure 2. The chemical structure of D-Allose.  D-Allose can be isolated from protea rubroprilosa

And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing ” D-Allose or its analogues, either alone or in combination with other anti-ageing/longevity promoting compounds, may be used to extend the lifespan of an individual (Figures 1-2).

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Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does D-Allose suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $300

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


References: 

CitationBoominathan, L., A sweet way to decrease blood pressure/sugar and extend lifespan: Sugar-based Lifespan extension therapy:  D-Allose, a C-3 epimer of glucose,  prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 4/April/2018, 12.19 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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