Site is Being Upgraded

A sweet way to say no to blood sugar disease: Sugar-based therapy for TIIDM: D-Mannose, a C-2 epimer of glucose,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 14/April/2018, 11.28 pm

Bonding your way to extend your lifespan and healthspan: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, may increase life span, via up-regulation of its target gene BubR1 and others, 14/April/2018, 11.16 pm
April 14, 2018
Treating pain with Endorphins: Endorphin-based activation of the PD-1 pathway for Pain therapy: β-Endorphin, an endogenous opioid neuropeptide and peptide hormone known to play a role in hunger, thrill, pain, maternal care, reward, and cognition, increases the expression of PD-L1, attenuates acutes and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 14/April/2018, 11.47 pm
April 14, 2018
Show all

IntroductionWhat they say:  

A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis regulates glucose metabolism.” This study was published, in the 30 September  2011 issue of the Journal “Cell” [One of the best journals in Biological sciences with an I.F of 28.71] by Prof George Q, the present Dean of the Harvard Medical School, Zhu H, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A sweet way to say no to blood sugar disease: Sugar-based therapy for TIIDM: D-Mannose, a C-2 epimer of glucose,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28

 

 


From significance of the study to Public health relevance: 

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells and cardiomyocytes that were lost in DM (Diabetes Mellitus) and MI (Myocardial infarction), respectively; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

Prof. George Q and his research team members had shown earlier that loss of Lin28 in muscles promotes insulin resistance and glucose intolerance. 


From Research findings to Therapeutic opportunity:

This study suggests, for the first time, that  D-Mannose, by increasing the expression of its target gene, it may (1) increase the expression of IGF1R, INSR, and IRS2; (2) enhance tissue repair; (3) promote regeneration of pancreatic β-cells; (3) augment regenerative capacity; (4) promote insulin sensitivity; and (5) protect against dilated cardiomyopathy (DCM) (Fig.1).

Thus, pharmacological formulations encompassing ” D-Mannose or  its analogues, either alone or in combination with other drugs,” may be used to treat DM and DCM.

Figure 1. Mechanistic insights into how  D-Mannose functions as an anti-diabetic and  cardioprotective agent.  D-Mannose may promote insulin sensitivity and protect against myocardial infarction via up regulation of reprogramming protein Lin-28

Figure 2. The chemical structure of D-Mannose.  D-Mannose may function as an anti-hyperglycemic agent through induction of Lin-28


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $ 500#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does  D-Mannose promote insulin-sensitized state?

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com/

 

CitationBoominathan L, A sweet way to say no to blood sugar disease: Sugar-based therapy for TIIDM: D-Mannose, a C-2 epimer of glucose,  increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 14/April/2018, 11.27 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.