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An elavil-way to extend lifespan and healthspan: Amitriptyline (trade name: Elavil), used in the treatment of major depressive disorder, anxiety disorder, migraines, neuropathic pain, and others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 16/April/2017, 9.55 am

An oxytocin-way to say no to cardiac diseases: Oxytocin-based inhalation therapy for attenuating pathogenesis-associated with Myocardial infarction: Inhalation of oxytocin decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up regulation of its target gene, 16/April/2018, 8.05 am
April 16, 2018
Adjunctive therapy for Malaria: Aspirin, an anti-inflammatory drug used in the treatment of fever, pain, and others, increases Ferroportin expression, decreases intracellular iron accumulation, inhibits cellular damage, prevents hemolysis, and inhibits malaria infection, via upregulation of its target gene, 16/April/2018, 10.31 am
April 16, 2018
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What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: An elavil-way to extend lifespan and healthspan: Amitriptyline (trade name: Elavil), used in the treatment of major depressive disorder, anxiety disorder, migraines, neuropathic pain, and others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene


Research findings to Therapeutic opportunity: 

Amitriptyline (brand name: Elavil), by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

Figure 1. Mechanistic insight into how  Amitriptyline/Elavil may extend lifespan. Amitriptyline/Elavil inhibits p70 S6 kInase expression and increases the expression of other longevity- promoting genes

Figure 2. The chemical structure of Amitriptyline/Elavil. Amitriptyline/Elavil functions as a longevity promoting agent through down regulation of p70S6 kinase

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Thus, pharmacological formulations encompassing “Amitriptyline/Elavil   or its analogues,  either alone or in combination with any of the known longevity-promoting compound(s), may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic Information: How  Amitriptyline/Elavil decreases the expression of p70 S6 Kinase and promotes mammalian life span

# Research cooperation

Amount: $500#

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References:

CitationBoominathan, L.,   An elavil-way to extend lifespan and healthspan: Amitriptyline (trade name: Elavil), used in the treatment of major depressive disorder, anxiety disorder, migraines, neuropathic pain, and others, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 16/April/2017, 9.55 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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