Cotton-derived compound functions as an anti-HIV agent: Gossypol, a natural compound isolated from cotton, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 3/April/2017, 10.08 pm

What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Cotton-derived compound functions as an anti-HIV agent: Gossypol, a natural compound isolated from cotton, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene

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From Significance of the study to Public health relevance:

Given that: (1) more than 37 million people worldwide are living with HIV/AIDS; (2) there is no effective vaccine available for HIV/AIDS; (3) HIV/AIDS tops the list of incurable diseases in humans; (4) the life-long painful drug treatment is required to treat HIV/AIDS and its associated opportunistic infections; (5) the global economic cost spent for HIV treatment is enormous, there is an urgent need to find: (i) a way to restore CD4 T-cells that were lost in HIV/AIDS; (ii) a cheaper alternative to the existing expensive antiviral drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, HIV-1/AIDS.

From Research findings to Therapeutic opportunity:

This study suggests a natural product-based antiviral therapy against RNA viruses, such as HIV-1.

Gossypol, by increasing the expression of its target gene, it may increase the expression of Heme oxygenase-2 (HO-2) (Figure 1). Thereby, it may: (1) bind and block the myristate moiety of HIV-1 Gag protein; (2) disrupt HIV-1 budding; (3) restrict HIV-1 infectivity, replication and production; (4) promote clearance of HIV-1 and MLV virions; and (5) strengthen antiviral immunity against RNA viruses. Thus, pharmacological formulations encompassing “Gossypol or its analogues, either alone or in combination with other anti-HIV drugs,” may be used to treat HIV infection.

Figure 1 Mechanistic insights into how Gossypol functions as an anti-HIV agent. Gossypol inhibits HIV-1 budding and production via up-regulation of its target gene HO-2

Figure 2. Gossypol functions as an anti-HIV1 agent through induction of HO-2.

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does Gossypol increase the expression of Heme oxygenase-2 (HO-2)?

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References:

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Citation: Boominathan, L.,  Cotton-derived compound functions as an anti-HIV agent: Gossypol, a natural compound isolated from cotton, increases Heme oxygenase 2 (HO-2) expression, blocks N-myristoylation of HIV-1 Gag protein, disrupts HIV-1 budding, and restricts HIV-1 production via up regulation of its target gene, 3/April/2017, 10.08 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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