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Bonding your way to decrease blood pressure/sugar and extend lifespan: Oxytocin-based Lifespan and healthspan extension therapy: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 13/April/2018, 7.09 am

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Molecular therapy for Metastatic cancers: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/April/2017, 8.39 am
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Significance of the study:

It has been shown earlier that antagonizing angiotensin II type I receptor (AT1R) expression may prolong mammalian life span. Further, it has been shown that disruption of AT1R (AGTR1) gene results in marked prolongation of mammalian lifespan. 


From research findings to therapeutic opportunity: 

This study suggests, for the first time, that oxytocin, by increasing the expression of its target genes,  it may decrease the expression of AT1R.

 

Figure1. Mechanistic insights into how oxytocin functions as a longevity-promoter. Oxytocin, by increasing the expression of its downstream target genes, down regulates A1TR expression and promotes longevity

Figure 2. The chemical structure of oxytocin. Oxytocin functions as an anti-hypertensive agent through down regulation of AT1R

And, thereby, it may: (1) decrease blood pressure; (2) decrease blood sugar levels; (3) inhibit pulmonary fibrosis; (4) enhance bacterial immunity; (5) inhibit myocardial infarction; (6) decelerate ageing process; and (4) extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Oxytocin or its activators, either alone or in combination with other anti-ageing/longevity promoting compounds, may be used to extend the lifespan of an individual (Figures 1-2).

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Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.  

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How  does oxytocin suppress the expression of  angiotensin II type I receptor (AT1R)? 

Amount: $300

For purchase and payment details, you may reach us at info@genomediscovery.org

#  Research cooperation


References: 

CitationBoominathan, L., Bonding your way to decrease blood pressure/sugar and extend lifespan: Oxytocin-based Lifespan and healthspan extension therapy: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 13/April/2018, 7.09 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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