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Bonding your way to extend your lifespan and healthspan: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/April/2017, 11.25 pm

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What they say? 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Bonding your way to extend your lifespan and healthspan: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span


Research findings to Therapeutic opportunity: 

Oxytocin, by  increasing  the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).   

Figure 1. Mechanistic insight into how Oxytocin may extend lifespan. Oxytocin inhibits p70 S6 kInase expression and regulates other genes that promote longevity

Figure 2. The chemical structure of Oxytocin. Oxytocin may function as a longevity promoting agent

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Thus, pharmacological formulations encompassing “Oxytocin   or its activators,  either alone or in combination with any of the known longevity-promoting compound(s), may be used to extend the lifespan of an individual (fig. 1).


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How  Oxytocin decreases the expression of p70 S6 Kinase and promote mammalian life span

# Research cooperation

Amount: $500#

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References:

CitationBoominathan, L.,   Bonding your way to extend your lifespan and healthspan: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span, 13/April/2017, 11.24 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or newbioideas.com/

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