Site is Being Upgraded

Molecular therapy for blood-stage Plasmodium infection: Oleic acid, isolated from olive oil, avocado and others,  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 22/April/2018, 11.03 pm

Mechanistic insights into how  Brimonidine functions as an anti-glaucoma agent: Brimonidine (trade name: Alphagan and Alphagan-P), used in the treatment of open-angle glaucoma and ocular hypertension,  increases Nmnat1 expression, increases NAD+ levels, improves neuronal dysfunction, and protects against glaucoma,  via down regulation of its target gene, 21/April/2018,  8.54 am
April 21, 2018
Molecular therapy for Deafness: A therapeutic mix encompassing Clofibrate, Cholecalciferol, Ajoene and DIM (CCAD) increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via up regulation of its target genes, 22/April/2018, 11.12 pm
April 22, 2018
Show all

Introduction: What they say

A study from the Department of Microbiology and Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA shows that “Regulatory T cells impede acute and long-term immunity to blood-stage malaria through CTLA-4.” This research paper was published, in September 2017 issue of the journal “Nature Medicine” [One of the best research journals in General biology with an I.F of 28.710], by Prof. Harty J and his research team members.

In connection with the study presented above, Prof. Harty J’s research team members had earlier shown that “Therapeutic blockade of PD-L1 and LAG-3 rapidly clears established blood-stage Plasmodium infection.” This research paper was published in December 2011 issue of the journal “Nature Immunology” [One of the best research journals in General biology with an I.F of 28.710].


What we say:

On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Molecular therapy for blood-stage Plasmodium infection: Oleic acid, isolated from olive oil, avocado and others,  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene


From significance of the study to Public health relevance:

Given that: (1) 214 million new cases of malaria had been reported in 2015; (2) nearly 438,000 people out of 214 million people who were infected with Malaria had died in 2015; (3) malaria has the potential to affect nearly half the global population; (4) molecular pathways involved and the mechanism of development of drug-resistant malaria are far from understood; (4) treating drug-resistant malaria is still a daunting task; (5) millions of deaths occur due to malaria every year; (6) out of the 125 million international travellers who visit countries, such as Ivory Coast, Angola, Burkina Faso, Burkina Faso, Mozambique and Mali, more than 30, 000 contract the disease; (7) most of the malaria cases are registered in developing countries, such as sub-Saharan Africa—that cannot afford high-cost required for the treatment of drug-resistant malaria—,compared to developed countries, such as US (10,000 malaria cases/ per year) and UK (1,500 malaria cases/year), (8) humans could not mount immunity against blood stage-malaria; and prevent re-infections; (9) billions of dollars are being spent each year globally for the treatment of Malaria, there is an urgent need to find: (i) a way to inhibit drug-resistant malaria; and (ii) a side-effect-free-Natural product-based drug that prevents relapse/recurrence of blood-stage/drug-resistant Malaria.


What is known?

Prof. Hardy’s research team has shown that blockade of CTLA-4, PD-1 ligand PD-L1 and the inhibitory receptor LAG-3: a) promote CD4+ T-cell function; b) increase the number of follicular helper T cells, germinal-center B cells etc.,; c) enhance the levels of protective antibodies; d) augment parasite clearance; e) promote species-transcending immunity to blood-stage malaria; f) prevent reinfection through potentiation of adaptive immunity; and g) clear blood-stage malaria, suggesting that inhibiting the expression of immune evasion molecules, such as CTLA-4, PD-1, PD-L1 and LAG-3, may attenuate chronic malaria-driven T-cell dysfunction; and promote parasite clearance in blood-stage malaria.


From research findings to Therapeutic opportunity:

This study suggests an oleic acid-based therapy for blood-stage malariaOleic acid, by increasing the expression of its target gene, it may decrease the expression of immune evasion molecules, such as CTLA-4, PD-1, PD-L1 and LAG-3 (Figure 1). Thereby, it may: (1) increase CD4+ T-cell function; (2) augment the number of helper T cells, germinal-center B cells etc.,; (3) increase secretion of protective antibodies; (4) promote plasmodium parasite clearance; (5) mount acute and long-term immunity to blood-stage malaria; (6) stifle reinfection through induction of adaptive immunity;(7) clear blood-stage malaria. Thus, pharmacological formulations encompassing “Oleic acid or its analogues, either alone or in combination with other antimalarial drugs,” may be used to treat blood-stage malaria (Figures 1-2).  Given the non-toxic nature of Glucosamine compared to other anti-malarial agents, it may be agent of choice to treat malaria.

[easy_payment currency=”USD”]

Figure 1 Mechanistic insights into how Oleic acid inhibits blood stage malaria. Oleic acid inhibits the expression of CTLA-4, PD-1, PD-L1 and LAG-3 via up regulation of its target genes

Figure 2. The chemical structure of Oleic acid. Oleic acid may function as an anti-malarial agent through down regulation of PD-L1, CT-LA4 and LAG3.

 


Details of the research findings:

Undisclosed mechanistic information: How does oleic acid decrease the expression of CTLA-4, PD-1, PD-L1 and LAG-3?

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $750#

For payment and purchase details, you may reach us at admin@genomediscovery.org

# Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  Molecular therapy for blood-stage Plasmodium infection: Oleic acid, isolated from olive oil, avocado and others,  decreases the expression of CTLA-4, PD-L1 and LAG-3, promotes CD4+ T-cell function, increases secretion of protective antibodies, promotes and clear blood-stage malaria via up regulation of its target gene, 22/April/2018, 11.03 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite, drop us a line at admin@genomediscovery.org

Comments are closed.