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Molecular therapy for Metastatic cancers: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/April/2017, 8.39 am

Bonding your way to decrease blood pressure/sugar and extend lifespan: Oxytocin-based Lifespan and healthspan extension therapy: Oxytocin,  a peptide hormone and neuropeptide known to play a role in empathy, generosity, child birth and so on, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 13/April/2018, 7.09 am
April 13, 2018
Natural product-derived therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing Baicalein, Salidroside and Carnosic acid (BCSSCA)  decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 13/April/2018, 9.23 am
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From Significance of the study to Public health relevance: 

Given that: (i) each year nearly 14 million people are diagnosed with cancer globally, and little more than half of them will die; (ii) cancer deaths globally are expected to be doubled by 2030; (iii) most of the cancer patients die due to metastasis; (iv) cancer treatment causes the highest economic loss compared to all the known causes of death worldwide, there is an urgent need to find: (i) bio-molecules that drive metastatic process; and the the way to prevent their expression; (ii) a way to activate immune system to combat cancer (Cancer immunotherapy); (ii) a cheaper alternative to the existing expensive anticancer drugs; (ii) a side-effect-free natural product-based drug; (iii) increase the therapeutic index of anticancer drugs; and (iv) a way to effectively treat and prevent metastatic progression and relapse of advanced/drug-resistant cancers.


Research findings to Therapeutic opportunity: 

This study suggests, for the first time, that  the anti-hypertensive drug valsartan, by regulating the expression of its target genes, it may increase the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1 (fig. 1).

Fig1. Mechanistic insights into how the anti-hypertensive medication Torsemide functions as an anti-metastasis agent. Valsartan increases the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1 via up regulation of its target genes

 

Thereby, it may: (a) inhibit cell cycle progression; and (b) suppress migration, invasion and metastasis of cancer cells.   [easy_payment currency=”USD”]

Given the anti-metastatic activity associated with valsartan, it may be an ideal anti-cancer agent to  (i) increase the expression of metastasis suppressor genes in tumors; (ii) inhibit the progression of metastatic tumors; and (ii) enhance the efficacy of cancer therapy.

Taken together, this study suggests that oncologists may consider treating terminally ill metastatic cancer patients with valsartanto stall the progression of advanced metastatic cancers.


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D

Amount: $10#

Undisclosed mechanistic information: How valsartan increases the expression of  tumor/metastatic suppressors TAp63, TAp73α and TPM1

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References: 

CitationBoominathan, L., Molecular therapy for Metastatic cancers: Valsartan, a medication used in the treatment of high blood pressure and congestive heart failure, increases the expression of tumor/metastatic suppressors TAp63, TAp73α and TPM1, inhibits cell cycle progression, and suppresses migration, invasion and metastasis of cancer cells via up regulation of its target gene, 13/April/2017, 8.41 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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