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A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found abundantly in oats and barley, may  suppress tumor suppressor INK4a/p16 expression, inhibit dilated cardiomyopathy and extend life span, via up regulation of its target gene, 23/May/2018, 12.37 pm

A handful of fiber-rich Oats and barley a day keeps the cardiac diseases at bay: Fiber-based Regenerative therapy for regaining the lost cardiomyocytes in Myocardial patients:  β-glucan, found abundantly in Oats and barely, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes via down regulation of its target gene, 23/May/2018, 12.10 am
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What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found abundantly in oats and barley, may  suppress tumor suppressor INK4a/p16 expression, inhibit dilated cardiomyopathy and extend life span, via up regulation of its target gene


From the Significance of the study to Public health relevance:

Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) the raise  of death rate, due to cardiovascular disease, has increased from 12.3 million in 1990 to 17.3 million in 2013; (4) 13% of cardiovascular disease occur due to  uncontrolled high blood pressure; (5) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (6) 85% of people over  80 years are susceptible to cardiovascular diseases; (7) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (8) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; and (9) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find:  (i) a cure to diseases, as mentioned above, leading to cardiovascular disease; (ii) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (iii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From research findings to therapeutic opportunity:  

This study suggests, for the first time, that β-glucan, by increasing the expression of their target gene, they may increase the expression of oncoprotein BMI-1 and suppress the expression of tumor suppressor  and the ageing marker INK4a/p16 (figure 1 ).

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Figure 1. Mechanistic insight into how β-glucan may function as cardioprotective agents. β-glucan inhibit dilated cardiomyopathy and heart failure via down regulation of ageing/senescence marker INK4a

Figure 2. The chemical structures of β-glucan

 

 

 

 

 

 


Thereby, they may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility.

Thus, (1) by encouraging myocardial patients to consume β-glucan, one may prevent Dilated  cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function; and (2) pharmacological formulations encompassing “β-glucan or its analogues, either alone or in combination with other drugs,” may be used to inhibit dilated cardiomyopathy and heart failure (figure 1). [easy_payment currency=”USD”]

 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How β-glucan increases the expression of oncoprotein BMI-1, while decreasing the expression of tumor suppressor INK4a

Amount: $500#

# Research cooperation

For purchase and payment details, you may reach us at admin@genomediscovery.org


References:

Web: http://genomediscovery.org or newbioideas.com

Citation: Boominathan, L., A fibrous way to strengthen your heart and extend lifespan: β-glucan-based therapy for cardiomyopathy: β-glucan, found abundantly in oats and barley, may  suppress tumor suppressor INK4a/p16 expression, inhibit dilated cardiomyopathy and extend life span, via up regulation of its target gene, 23/May/2018, 12.37 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

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