Site is Being Upgraded

A sweet way to say no to Diabetes-too good to be true: Oligofructose-based regenerative therapy for reversing diabetes: Agavin (Oligofructose), a new natural sugar isolated form agavi, increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 16/May/2018, 3.03 pm

Artemether-based therapy for autoimmune diabetes (TIDM): Artemether, a methyl ether-derivative of artemisinin isolated from artemisia annua, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 15/May/2018, 6.47  am
May 15, 2018
Milk hormone comes to the rescue of blood sugar disease: Prolactin-based adjunct therapy for autoimmune diabetes (TIDM): Prolactin, a milik hormone, increases PD-L1 expression, increases Tregs function, promotes immune tolerance, increases pancreatic β-cell proliferation and regeneration, increases insulin secretion, improves insulin sensitivity, increases energy utilization, and reverses TIDM, via up regulation of its target gene, 16/May/2018, 3.42  pm
May 16, 2018
Show all

Introduction: What they say

A study from the Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, 3715 McClintock Avenue, Los Angeles, California, USA; and Koch Institute at MIT, 500 Main Street, Cambridge, USA shows that “Fasting-Mimicking Diet Promotes Ngn3-Driven ß-Cell Regeneration to Reverse Diabetes.” This research paper was published, in the 23 February 2017 issue of the journal “Cell” [One of the best research journals in Biology with an I.F of 28 plus], by  Prof. and Director of Longevity institute Valter Longo, Cheng CW and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A sweet way to say no to Diabetes-too good to be true: Oligofructose-based regenerative therapy for reversing diabetes: Agavin (Oligofructose), a new natural sugar isolated form agavi, increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene

 

[easy_payment currency=”USD”]


From significance of the study to Public health relevance:

Given that: (1) more than 387 million people worldwide are affected by Diabetes mellitus (DM); (2) Diabetes is going to be one of the top 10 causes of death by 2030; (3) the life-long painful injection/drug treatment is required to treat DM; (3) the global economic cost spent for diabetes treatment in 2014 was little more than 600 billion US dollars, there is an urgent need to find: (i) a way to induce regeneration of adult ß-cells that were lost in DM; (ii) a cheaper alternative to the existing expensive weight-loss drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, diabetes.


What is known?

It has recently been shown that fasting mimicking diet (FMD):(1) increases the expression of Sox17, Pdx-1 (Pancreatic And Duodenal Homeobox 1), & Ngn3 (Neurogenin-3) sequentially; (2) promotes regeneration of insulin-producing ß cells; (3) decreases PKA (Protein Kinase A) and mTOR activity; (4) increases reprogramming proteins Sox2 and Ngn3 expression; (5) increases insulin secretion; and (6) promotes glucose homeostasis, suggesting that FMD: (i) promotes reprogramming of pancreatic cells to restore insulin secretion in islets; and (ii) can reverse both T1D and T2D.


From research findings to Therapeutic opportunity:

This study suggests, for the first time, an oligofructose (Agavin)-based regenerative therapy for T1D and TIID. Agavins, isolated from Agave plant, have been shown to decrease blood sugar and promote weight loss. However, the mechanism of action remains elusive.

Agavins, by increasing the expression of their target genes, they may increase the expression of Sox17, Ngn3, Sox2, Pdx-1, NKX6.1, Pax6, INS etc. (Fig. 1). Thereby,  they may: (1) decrease the expression of mTOR;  (2) increase generation of insulin-producing ß cells; (3) increase insulin secretion; and (4) promote glucose homeostasis, suggesting that Agavins-based therapy–may replace the need for FMD (Fast mimicking diet) or function as an effective alternative to FMD–may find their use in clinic in attenuating and/or reversing both T1D and T2D, as they turn on most of the reprogramming/insulin-producing genes turned by the FMD (Fig.1).

Figure 1. Mechanistic insights into Agavins, by turning on the expression of Ngn3, NKX6.1, Pax6, and INS and others anti-diabetic genes, may promote reprogramming of pancreatic cells to restore insulin secretion in islets; and reverse both T1D and T2D.

Figure 2. Agavins-based therapy for Diabetes.

 

 

 

 

 

 

 

 

 

 

 

 

Thus, Agavins, either alone or in combination with other compounds, may be used to treat and cure T1D and T2D (Fig.2). Together, this study suggests, for the first time, that agavins-based therapy may be used to treat and/or cure T1D and T2D.

[easy_payment currency=”USD”]


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Agavins increase the expression of Sox17, Sox2, Pdx-1, and Ngn3?

Amount: $750#

# Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., A sweet way to say no to Diabetes-too good to be true: Oligofructose-based regenerative therapy for reversing diabetes: Agavin (Oligofructose), a new natural sugar isolated form agavi, increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D via down regulation of its target gene, 16/May/2018, 3.03 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, drop us a line at info@genomediscovery.org

Comments are closed.