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Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Hydrogen-rich saline increases the expression of tumor suppressors genes, such as  p53, TA-p73 and TA-p63, TIMP3, and CCM3/KRIT1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 20/May/2017, 4.56 pm

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From Significance of the study to Public health relevance

Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant p53-overexpressing tumors; (4) cancer causes the highest economic loss compared to all the known causes of death worldwide; and (5) cancer causes the considerable economic loss worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and stall metastatic progression and relapse of mutant p53-overexpressing human cancers.


From therapeutic strategy to Research Findings:

(i) Therapeutic strategy: 

This study suggests a therapeutic strategy for stalling the progression of p53-deficient/deleted or mutant-p53 expressing metastatic cancers. By activating tumor suppressor p53’s unmutated “homologous protein such as TAp73/p63” in p53-deficient or mutant-p53 expressing metastatic cancer cells, one can stall their progression.

(ii) Research findings:  

This study suggests, for the first time, to the best of our knowledge, that hydrogen-rich saline may function as an anti-cancer/metastasis agent.  Hydrogen-rich saline, by increasing the expression of its target gene, it may increase the expression of tumor/metastasis suppressors genes, such as  p53, TA-p73 and TA-p63, TIMP3, and CCM3/KRIT1 and others. Thereby, it may inhibit the migration and invasion of metastatic cancer cells expressing mutant-p53 (figure1).

Figure 1. Mechanistic insight into how hydrogen-rich saline functions as an anticancer/antimetastatic agent in mutant p53-expressing tumors.  Hydrogen-rich saline,  by activating tumor/metastasis suppressor genes, such as p53, TA-p73 and TA-p63, TIMP3, and CCM3/KRIT1, and others, in  metastatic tumors, it may inhibit the progression of mutant-p53 expressing human cancers.


Therapeutic opportunity:

Given the ability of hydrogen-rich saline to induce the expression of a number of tumor/metastasis suppressor genes, it may be used, either alone or in combination with other anticancer drugs, to inhibit the progression of p53-mutated invasive metastatic tumors. Taken together, this study suggests, for the first time, that oncologists may consider treating terminally ill metastatic cancer patients with hydrogen-rich saline, as it may stall the progression of advanced metastatic cancers.


Details of the research findings

Idea Proposed/Formulated by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $300#

Undisclosed mechanistic information: How hydrogen-rich saline increases the expression of tumor suppressor genes, such as   p53, TA-p73 and TA-p63, TIMP3, and CCM3/KRIT1, and others,  in mutant p53 expressing cancer cells?

For purchase and payment details, you may reach us at admin@genomediscovery.org

#Research cooperation


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Hydrogen-rich saline increases the expression of tumor suppressors genes, such as  p53, TA-p73 and TA-p63, TIMP3, and CCM3/KRIT1, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 20/May/2017, 4.56 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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