A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins (Oligofructose),isolated from agavi, may  suppress tumor suppressor INK4a/p16 expression, and inhibit dilated cardiomyopathy, via up regulation of its target gene, 20/May/2018, 3.36 pm

A glycolipid-based therapy for glucose homeostasis and TIIDM: α-Galactosylceramide (α-gal-cer), a synthetic glycolipid, increases Pax6 and insulin expression, decreases the levels of glucagon, ghrelin and Somatostatin, reduces metabolic stress, improves insulin sensitivity, promotes glucose homeostasis and prevents progression to TIIDM via down regulation of its target gene, 18/May/2018, 2.03 pm
May 18, 2018
Molecular therapy for cardiomyocyte proliferation and heart regeneration: A pharmaceutical mixture encompassing   3,3′-Diindolylmethane (DIM) Sodium nitrite(NaNO2), and  Sodium Sulfide (DIMSNSS) decreases tumor suppressor MiR-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up regulation of its target gene, 20/May/2018, 4.29 pm
May 20, 2018
Show all

What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for Cardiomyopathy: Agavins (Oligofructose), isolated from agavi, may  suppress tumor suppressor INK4a/p16 expression, and inhibit dilated cardiomyopathy, via up regulation of its target gene


From the Significance of the study to Public health relevance:

Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) the raise  of death rate, due to cardiovascular disease, has increased from 12.3 million in 1990 to 17.3 million in 2013; (4) 13% of cardiovascular disease occur due to  uncontrolled high blood pressure; (5) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (6) 85% of people over  80 years are susceptible to cardiovascular diseases; (7) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (8) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; and (9) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find:  (i) a cure to diseases, as mentioned above, leading to cardiovascular disease; (ii) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (iii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From research findings to therapeutic opportunity:  

This study suggests, for the first time, that  Agavins, by increasing the expression of their target gene, they may increase the expression of oncoprotein BMI-1 and suppress the expression of tumor suppressor  and the ageing marker INK4a/p16 (figure 1 ).

[easy_payment currency=”USD”]

Figure 1. Mechanistic insight into how Agavins may function as cardioprotective agents. Agavins inhibit dilated cardiomyopathy and heart failure via down regulation of ageing/senescence marker INK4a

Figure 2. The chemical structures of Agavins

 

 

 

 

 


Thereby, they may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility.

Thus, (1) by encouraging myocardial patients to consume agavins, one may prevent Dilated  cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function; and (2) pharmacological formulations encompassing Agavins or their analogues, either alone or in combination with any of the known drugs that are used to treat cardiomyopathy,” may be used to inhibit dilated cardiomyopathy and heart failure (figure 1). [easy_payment currency=”USD”]

 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How Agavins  increase the expression of oncoprotein BMI-1, while decreasing the expression of tumor suppressor INK4a

Amount: $500#

# Research cooperation

For purchase and payment details, you may reach us at admin@genomediscovery.org


References:

Web: http://genomediscovery.org or newbioideas.com

Citation: Boominathan, L., A sweet way to strengthen your heart-too good to be true(!): Oligofructose-based therapy for life-span extension: Agavins (Oligofructose), isolated from agavi, may  suppress tumor suppressor INK4a/p16 expression, and inhibit dilated cardiomyopathy, via up regulation of its target gene, 20/May/2018, 3.36 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Comments are closed.