Hypertonic saline-based therapy protects your heart from cardiac diseases and cardiac ageing:  Hypertonic saline (10%) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 8/May/2018, 7.14 pm

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What they say

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of the journal Nature,  by Prof Dimmler, Boon, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Hypertonic saline-based therapy protects your heart from cardiac diseases and cardiac ageing:  Hypertonic saline (10%) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 8/May/2018, 7.14 pm


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From Significance of the study to Public Health relevance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from  123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From Research Findings to Therapeutic Opportunity

This study provides suggests, for the first time, that Hypertonic saline (10%) may protect against myocardial infarction and cardiac ageing.

Figure 1. Hypertonic saline (10%) functions as a Cardioprotective agent. Mechanistic insights into how Hypertonic saline (10%)  induces the expression of PNUTS and Telomerase to prevent myocardial infarction and promote Cardiac regeneration/survival

Figure 2. Hypertonic saline (10%) may function as a cardioprotective agent through induction of PNUTS

 

 

 

 

 

 

 

 

 

 

Hypertonic saline (10%), by increasing the expression of its target genes, it may increase the expression of PNUTS (fig.1)Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration; (5) decelerate ageing; and (6) extend life span (fig 1). 

Thus, by treating cardiac patients with Hypertonic saline (10%), one may prevent ageing-associated (or, stress-associated) decline in cardiac function.
Together, this study suggests, for the first time, that pharmacological formulations encompassing “Hypertonic saline (10%), either alone or  in combination with other drugs,”  may be used to improve cardiac function after myocardial infarction (fig. 2).   Given  the mechanism of action of hypertonic saline; and its cost-effective nature, it may be an agent of choice for cardiologists to improve cardiac function after myocardial function. 

Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does  Hypertonic saline (10%) increase the expression of PNUTS/Telomerase

Amount: $1, 500#

# Research cooperation

For purchase and payment details, you may reach us at admin@genomediscovery.org


References

Web:http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,   Hypertonic saline-based therapy protects your heart from cardiac diseases and cardiac ageing:  Hypertonic saline (10%) inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 8/May/2018, 7.14 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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