Feel-good hormone may help you live longer: Oxytocin-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Oxytocin, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (OCIMDULMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 7/June/2017, 5.58 am
Cluster of differentiation-based therapy for body weight control, energy homeostasis and TIIDM: Cluster of differentiation (CD24) decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 6/June/2017, 11.52 pm
June 6, 2018
Interleukin-based therapy for body weight control, energy homeostasis and TIIDM: Interleukin-2(IL-2) decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up regulation of its target gene, 7/June/2018, 6.38 am
June 7, 2018Introduction: What they say
A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”, by Prof. Jung YK, Pyo Jo and others.
Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of of ATG5 in the regulation of autophagy.
What we say:
On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Feel-good hormone may help you live longer: Oxytocin-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Oxytocin, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (OCIMDULMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 7/June/2017, 5.58 am
From research findings to therapeutic opportunity:
Oxytocin, a peptide hormone and neuropeptide, has been shown to play role in empathy, generosity, child birth and so on. This study suggests, for the first time, that a therapeutic mix encompassing Oxytocin, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (OCIMDULMC), by increasing the expression of its target genes, it may increase the expression of ATG5 (Autophagy related 5). Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features (Fig.1).
Figure1. A therapeutic mix encompassing Oxytocin, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (OCIMDULMC) functions as a longevity promoting agent. The therapeutic mix OCCMUDIL increases ATG5 expression and promotes leanness, insulin sensitivity, motor function and longevity.
Figure 2. A pharmaceutical mix OCIMDULMC may promote weight loss, insulin sensitivity, motor function and extend lifespan through induction of ATG5 and other longevity-promoting genes
Figure 3 The feel-good/power of positivity hormone Oxytocin functions as a longevity-promoter through induction of ATG5.
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Thus, pharmacological formulations encompassing “Oxytocin, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (OCIMDULMC)“ or their analogues, either alone or in combination with drugs” may be used to increase the lifespan of an individual (Fig.1).
Details of the research findings:
Idea Proposed/Formulated by: Dr L Boominathan PhD
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# Research cooperation
Undisclosed mechanistic information: How does a therapeutic mix encompassing OCIMDULMC increase the expression of ATG5 and promote longevity?
References:
Web: http://genomediscovery.org or newbioideas.com/
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Citation: Boominathan, L., Feel-good hormone may help you live longer: Oxytocin-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Oxytocin, Catalpol, Isoliquiritigenin, Maresin, DIM, Ursolic acid Lutein, Maresin, Cholecalciferol (OCIMDULMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 7/June/2017, 5.58 am
