Site is Being Upgraded

A flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others,  may  increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes, 12/July/2018, 12.53 pm

Flu vaccine comes to the rescue of blood sugar disease: Influenza A (H1N1) vaccine-based regenerative therapy for reversing diabetes:  Influenza A (H1N1) vaccine increases the expression of Sox17, Sox2, Pdx-1, and Ngn3, decreases mTOR expression, promotes regeneration of insulin-producing ß cells, increases insulin secretion, promotes glucose homeostasis and reverses T1D and T2D, via down regulation of its target gene, 12/July/2018, 12.37 pm
July 12, 2018
A flu vaccine-based therapy for lowering cholesterol, and triglycerides levels: Repurposing Influenza A/flu(H1N1) vaccine into a cholesterol-lowering vaccine that inhibits Non-alcoholic fatty liver disease (NAFLD): Influenza A/flu(H1N1) vaccine decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD), via down regulation of its target gene, 12/July/2018, 1.04 pm
July 12, 2018
Show all

 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston,USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the journal  “EMBO”, by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A  flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others,  may  increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, that Quercetinby increasing the expression of its target gene, may: (a) increase the expression of BuBR1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase); (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1).

Figure 1. Quercetin may extend  mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase

Figure 2. Quercetin functions as  longevity-promoter through induction of BuBR1.

 

 

 

 

 

 

 

 

Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, Quercetin or its analogues, either alone or in combination with other drugs, may be used to extend the lifespan of an individual (fig.2).

[easy_payment currency=”USD”]


Details on the research findings: 

Idea Proposed/Formulated (with experimental evidence) byDr L Boominathan Ph.D.

Amount: $750#

Undisclosed mechanistic information: How Quercetin increase the expression of BubR1 and extend mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

CitationBoominathan, L., A flavonoid way to lengthen lifespan: Quercetin, a flavonoid isolated from elder berries, onions and others,  may  increase insulin sensitivity, slow down cardiac aging, and increase life span, via up-regulation of BubR1 and others genes, 12/July/2018, 12.53 pm,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at admin@genomediscovery.org

Comments are closed.