A sweet way to extend lifespan-too good to be true: Polysaccharide-based therapy for lifespan and healthspan extension: Astragalus polysaccharide, isolated from astragalus membraneous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, 26/July/2018, 12.38 am
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July 25, 2018
Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others, increases the expression of tumor suppressors genes, such as CADM2, HNF4α, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down regulation of its target gene, 27/July/2018, 10.22 pm
July 27, 2018What they say?
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: A sweet way to extend lifespan-too good to be true: Polysaccharide-based therapy for lifespan and healthspan extension: Astragalus polysaccharide, isolated from astragalus membraneous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan
Research findings to Therapeutic opportunity:
Astragalus polysaccharide, by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Figure 1. Mechanistic insight into how Astragalus polysaccharide may extend lifespan. Astragalus polysaccharide inhibits p70 S6 kinase expression and regulates other genes that promote longevity
Figure 2. The chemical structure of Astragalus polysaccharide. Astragalus polysaccharide may function as a longevity promoting agent
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Thus, pharmacological formulations encompassing “Astragalus polysaccharide or its analogs, either alone or in combination with any of the known longevity-promoting compound(s),“ may be used to extend the lifespan of an individual (fig. 1).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic Information: How Astragalus polysaccharide decreases the expression of p70 S6 Kinase and promote mammalian lifespan
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References:
Citation: Boominathan, L., A sweet way to extend lifespan-too good to be true: Polysaccharide-based therapy for lifespan and healthspan extension: Astragalus polysaccharide, isolated from astragalus membraneous, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, 26/July/2018, 12.37 am, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
Web: http://genomediscovery.org or newbioideas.com/
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