Heat-shock inhibitors (HSPs) as longevity-promoters: HSP-90 inhibitor-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing 17-DMAG(HSP-90 inhibitor), Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan, via up regulation of its target gene ATG5 (Autophagy related 5), 18/July/2018, 7.34 am

Fiber-based anti-infective Therapy: β-(1,3)-glucan/Lentinan(LNT), isolated from Lentinus edodes, inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene 15, 17/July/2018,  6.09 pm
July 17, 2018
Flavonoid your way to decrease blood pressure/sugar and extend lifespan: Quercetin-based Lifespan and healthspan extension therapy: Quercetin,  a flavonoid isolated from elder berries and onions, decreases blood sugar and blood pressure levels and prolongs mammalian life span, via down regulation of angiotensin II type I receptor (AT1R), 18/July/2018, 7.47 am
July 18, 2018
Show all

Introduction: What they say

A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was published, in the online journal “Nature communications”,  by Prof. Jung YK, Pyo Jo and others.

Earlier, Prof. Yoshinori Ohsumi, from Institute of Innovative Research, Tokyo Institute of Technology, who won the Nobel prize in Physiology or Medicine, in 2016, discovered the mechanisms of Autophagy, including the role of of ATG5 in the regulation of autophagy.


What we say: 

On the foundation of these interesting findings, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:   Heat-shock inhibitors (HSPs) as longevity-promoters: HSP-90 inhibitor-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing 17-DMAG(HSP-90 inhibitor), Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5)


From research findings to therapeutic opportunity: 

.This study suggests, for the first time, that a therapeutic mix encompassing   17-DMAG (HSP-90 inhibitor), Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC), by increasing the expression of its target genes, it may increase the expression of ATG5 (Autophagy related 5). Thereby, it may: (1) enhance autophagy, (2) promote leanness; (3) increase insulin sensitivity; (4) improve motor function; and (5) alleviate ageing features (Fig.1).

Figure1. A therapeutic mix encompassing 17-DMAG, Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC) functions as a longevity promoting agent. The therapeutic mix OCCMUDIL increases ATG5 expression and promotes leanness, insulin sensitivity, motor function and longevity.

Figure 2. A pharmaceutical mix 17-DMAGUCIMDLMC may promote weight loss, insulin sensitivity, motor function and extend lifespan through induction of ATG5 and other longevity-promoting genes

Figure 3 Natural product derived compound 17-DMAG functions as a longevity-promoter through induction of ATG5

17

 

 

 

 

 

 

 

[easy_payment currency=”USD”]

Thus, pharmacological formulations encompassing ” 17-DMAG, Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC)” or their  analogues, either alone or in combination with drugs” may be used to increase the lifespan of an individual (Fig.1).


Details of the research findings: 

Idea Proposed/Formulated by: Dr L Boominathan PhD

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $500#

For payment and purchase information, you may reach us at info@genomediscovery.org

# Research cooperation

Undisclosed mechanistic information: How does 17-DMAGUCIMDLMC increase the expression of ATG5 and promote longevity?


References: 

Web: http://genomediscovery.org or newbioideas.com/

Courtesy: When you cite us, just drop us a line at info@genomediscovery.org

Citation: Boominathan, L., Heat-shock inhibitors (HSPs) as longevity-promoters: HSP-90 inhibitor-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing 17-DMAG(HSP-90 inhibitor), Ursolic acid, Catalpol, Isoliquiritigenin, Maresin, DIM, Lutein, Maresin, Cholecalciferol (17-DMAGUCIMDLMC) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via up regulation of its target gene ATG5 (Autophagy related 5), 18/July/2018, 7.34 am

 

Comments are closed.