What they say?
A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports, for the first time, that: Inhibitors of heat shock response as longevity-promoters: 17-DMAG, a heat shock protein-90 (HSP-90) inhibitor, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene
Research findings to Therapeutic opportunity:
17-DMAG(17-Dimethylaminoethylamino-17-demethoxygeldanamycin), by increasing the expression of its target gene, it may suppress Ribosomal protein S6 kinase 1 (p70S6 Kinase) expression and regulate the expression of other longevity-promoting genes (fig.1). Thereby, it may promote: (1) resistance to bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).
Thus, pharmacological formulations encompassing “17-DMAG or its analogues, either alone or in combination with any of the known longevity-promoting compound(s),“ may be used to extend the lifespan of an individual (fig. 1).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic Information: How 17-DMAG decreases the expression of p70 S6 Kinase and promotes mammalian life span
# Research cooperation
For purchase and payment information, you may reach us at firstname.lastname@example.org
Citation: Boominathan, L., Inhibitors of heat shock response as longevity-promoters: 17-DMAG, a heat shock protein-90 (HSP-90) inhibitor, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian life span via up regulation of its target gene, 12/July/2017, 1.20 pm, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
Courtesy: When you cite drop us a line at email@example.com