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Protect your heart from Myocardial dysfunction and cardiac ageing with Tuberculosis BCG vaccine: BCG vaccine induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 2/July/2018, 11.55 am

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What they say

A recent study from the Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Frankfurt, Germany shows that “MicroRNA-34a regulates cardiac ageing and function.” This study was published, in the 7 March  2013 issue of of the journal Nature,  by Prof Dimmler, Boon, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Protect your heart from Myocardial dysfunction and cardiac ageing with Tuberculosis BCG vaccine: BCG vaccine induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS


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From Significance of the study to Public Health relevance:

Given that: (1)  cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from  123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.


From Research Findings to Therapeutic Opportunity

This study suggests, first the first time, Bacillus Calmette Guerin (BCG) vaccine-based therapy, with detailed mechanistic insights, for protecting myocardium following acute myocardial infarction; and cardiac ageing. BCG vaccine  has been found to be useful in the treatment of tuberculosis, for more than 100 years, more recently in the treatment of autoimmune diabetes. However, the mechanism of action remains largely unknown.

Figure 1. Bacillus Calmette Guerin (BCG) vaccine functions as a Cardioprotective agent. Mechanistic insights into how BCG induces the expression of PNUTS and Telomerase to protect against myocardial cell death and fibrosis following myocardial infarction; and to  promote Cardiac regeneration/survival.

Figure 2 Repurposing tuberculosis BCG vaccine into myocardium-protecting vaccine. BCG vaccine protects against myocardial dysfunction and promotes myocardial survival through induction of PNUTS and Telomerase.

BCG vaccine, by increasing the expression of its target genes, it may increase the expression of PNUTS (fig.1)Thereby, it may: (1) inhibit DNA damage responses, (2) increase telomerase expression, (3) inhibit telomere shortening; (4) promote cardiomyocyte survival/regeneration; (5) decelerate ageing; and (6) extend life span (fig 1). 

 

 

 

 

 

 

 

Thus, by vaccinating cardiac or aged patients who may be prone to myocardial dysfunction with BCG, one may prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests, for the first time, BCG, either alone or  in combination with other drugs,”  may be used to improve cardiac function after acute myocardial infarction (fig. 2).  


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) byDr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does BCG vaccine increase the expression of PNUTS/Telomerase

Amount: $500#

# Research cooperation

For purchase and payment details, you may reach us at admin@genomediscovery.org


References

Web:http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,  Protect your heart from Myocardial dysfunction and cardiac ageing with Tuberculosis BCG vaccine: BCG vaccine induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up regulation of PNUTS, 2/July/2018, 11.55 am,  Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org

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