Introduction: What they say:
A recent study from Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel; Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA; and Baylor College of Medicine and The Texas Heart Institute, Houston, Texas 77030, US shows that “The extracellular matrix protein Agrin promotes heart regeneration in mice.” This study was published, in the 5 June 2017 issue of Nature, by Prof Tzahor E, Bassat E and others.
What we say:
On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Safeguard your heart function with TB/BCG vaccine: TB/BCG vaccine based therapy for Cardiac repair and myocardial infarction: TB/BCG vaccine increases Agrin expression, activates Yap and ERK-mediated signaling, replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene
From Significance of the study to Public Health relevance:
Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) the raise of death rate, due to cardiovascular disease, has increased from 123 lakhs in 1990 to 173 lakhs in 2013; (3) 85% of people over 80 years are susceptible to cardiovascular diseases;(4) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (3) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; (4) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (5) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find: (i) a way to induce regeneration of cardiomyocytes that were lost in Myocardial patients; (ii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug that heals damaged heart tissue.
What is known?
Prof. Tzahor’s research team has shown recently that: (1) Agrin, one of the components of the neonatal Extracellular matrix (ECM) , promotes regeneration in mouse hearts; and (2) Agrin promotes cardiomyocytes regeneration after heart attack through disruption of dystrophin glycoprotein complex and activation of Yap and ERK-mediated signaling, suggesting that activation of Agrin may: (1) replace the damaged scar tissue, with functional cardiomyocytes, after myocardial infarction; and (2) protect an individual from myocardial infarction through cardiac rejuvenation and regeneration.
From research findings to Therapeutic Opportunity:
This study suggests, first the first time, Bacillus Calmette Guerin (BCG) vaccine-based regenerative therapy, with detailed mechanistic insights, for T1D and TIID. BCG vaccine has been found to be useful in the treatment of tuberculosis(TB), for more than 100 years, more recently in the treatment of autoimmune diabetes. However, the mechanism of action remains largely unknown.
TB/BCG vaccine, by increasing the expression of its target genes, it may increase the expression of Agrin (fig.1). Thereby, it may: (1) inhibit dystrophin glycoprotein complex;(2) increase Yap and ERK-mediated signaling; (3) increase the expression of gene products that promote cardiac regeneration and survival;(4) increase the expression of miRNAs that promote cardiac regeneration and survival;(5) increase cardiomyocyte proliferation; (6) replace scar tissue with heart muscle functional cardiomyocytes; (7) promote cardiomyocyte survival/regeneration; (8) promote recovery after myocardial infarction; and (9) extend lifespan (fig 1). Thus, by vaccinating myocardial patients with BCG vaccine, cardiologists may preserve myocardial function after myocardial infarction; and prevent ageing-associated (or, stress-associated) decline in cardiac function. Together, this study suggests, for the first time, that TB/BCG vaccine, either alone or in combination with other drugs,”may not only be used to heal the damaged cardiac tissue after myocardial infarction, and preserve myocardial function, but also be used to prevent cardiac ageing (fig. 2).
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
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Undisclosed mechanistic information: How TB/BCG vaccine increases the expression of Agrin and promotes cardiac regeneration and repair
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Citation: Boominathan, L., Safeguard your heart function with TB/BCG vaccine: TB/BCG vaccine based therapy for Cardiac repair and myocardial infarction: TB/BCG vaccine increases Agrin expression, activates Yap and ERK-mediated signaling, replaces scar tissue with functional cardiomyocytes, and promotes cardiomyocyte regeneration and repair after myocardial infarction, via up regulation of its target gene, 9/July/2018, 10.17 am, Genome-2-Bio-Medicine Discovery center (GBMD), http://genomediscovery.org
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