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August 3, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  ANP32A, VHL,  TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 3/August/2018, 1.30 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 3, 2018

Optimal levels of a reproductive hormone FSH(Follicle stimulating hormone) may keep cardiac diseases at bay: FSH-based cardiac rejuvenation therapy: FSH, a gonadotrophin and polypeptide hormone, suppresses tumor suppressor INK4a/p16 expression and inhibits dilated cardiomyopathy, via upregulation of its target gene, 3/August/2018, 1.25 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Optimal levels of a reproductive hormone FSH(Follicle stimulating hormone) may keep cardiac diseases at bay: […]
August 3, 2018

Unknown function of a known reproductive hormone: FSH (Follicle-stimulating hormone) may find its utility in cardiac regenerative therapy: FSH, a gonadotropin and glycoprotein polypeptide hormone, increases the expression of ERBB2/Her2 and promotes dedifferentiation  of cardiomyocytes, via down-regulation of its target gene, 3/August/2018, 1.04 pm

Introduction: What they say A recent study from the Department of Biological Regulation, Weizmann Institute of Science, Rehovot 76100, Israel shows that “ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.” This study was […]