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August 4, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as LATS1, SMARCA4, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 8/August/2018, 11.51 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 4, 2018

Assigning an unknown function to a known reproductive hormone Follicle-stimulating hormone (FSH) in Longevity: FSH-based therapy for aging-associated diseases and Lifespan extension: FSH increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 8/August/2018, 11.43 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
August 4, 2018

Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing  Macbecin, Temozolomide, EGCG, Salinomycin, Fluvastatin, and Chloroquine (MTESFC) inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 4/August/2018, 5.16 pm

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on […]
August 4, 2018

Reproductive hormone aids in control of body weight, energy homeostasis and TIIDM: Human chorionic gonadotrophin (hCG), normally used as a marker for pregnancy, decreases CADM1 and its downstream target genes that inhibit glucose-induced insulin secretion, improves insulin sensitivity, increases energy utilization, promotes weight loss and protects from diet-induced obesity and TIIDM, via up-regulation of its target gene, 4/August/2017, 12.30 pm

Introduction: What they say A study from the Max Delbrück Center for Molecular Medicine, Berlin, Germany shows that “Regulation of body weight and energy homeostasis by […]