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August 24, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  APAF1, FOXO1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 24/August/2018, 11.34 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 24, 2018

Repurposing the anti-angina drug Ranolazine into an analgesic drug: Ranolazine-based activation of the PD-1 pathway for Pain therapy: Ranolazine  increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/August/2018, 11.20 pm

 Introduction: What they say:  A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
August 24, 2018

The pregnancy hormone Relaxin relieves you of acute and chronic pain (No kidding): Relaxin-based activation of the PD-1 pathway for Pain therapy: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature,  increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 24/August/2018, 11.08 pm

 Introduction: What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
August 24, 2018

Combinatorial therapy for Deafness: A therapeutic mix encompassing Exemestane, Cholecalciferol, Ajoene and DIM (ECAD)  increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via upregulation of its target genes, 24/August/2018, 10.45 pm

What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Combinatorial therapy for Deafness: A therapeutic mix encompassing Exemestane, Cholecalciferol, Ajoene and DIM (ECAD)  increases the expression […]