A Lotus way to lengthen lifespan: The Lotus component Nucinferin-based therapy for life-span extension: Nucinferin, isolated from lotus leaf, may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 23/August/2018, 2.36 pm

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 What they say: Introduction: 

A recent study from the Department of Genetics, Paul F. Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, USA; and Department of Pharmacology, School of Medicine, The University of New South Wales, Australia shows that Sirtuin-2 induces the checkpoint kinase BubR1 to increase lifespan. This study was published, in the 1 July  2014 issue of the journal  “EMBO”, by Prof Sinclair, North BJ, and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: A Lotus way to lengthen lifespan: The Lotus component Nucinferin-based therapy for life-span extension: Nucinferin, isolated from lotus leaf, may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes

 


From research findings to Therapeutic Opportunity: 

This study suggests, for the first time, that Nucinferinby increasing the expression of their target gene, they may: (a) increase the expression of BuBR1; (b) decrease the expression of p70 S6 Kinase; and (c) regulate the expression of a number of longevity-promoting molecules (fig. 1).

Figure 1. Nucinferin may extend  mammalian life span via up regulation of BuBR1 and down regulation of p70 S6 Kinase

Figure 2. The Lotus leaf component Nuciferin function as a longevity-promoting agent.

 

 

 

 

 

 

 

 

Thereby, it may: (1) increase insulin sensitivity; (2) attenuate cognitive impairment; (3) delay diseases of aging; (4) slow down cardiac aging; (5) promote resistance to bone, immune and motor dysfunction; (6) promote tissue rejuvenation; and (7) prolong median life span. Thus, Nucinferin  or its analogs, either alone or in combination with other drugs, may be used to extend the lifespan of an individual (fig.2).

[easy_payment currency=”USD”]


Details on the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

Amount: $750#

Undisclosed mechanistic information: How Agavins increase the expression of BubR1 and extend mammalian life-span

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

# Research cooperation


References

Web: http://genomediscovery.org or http://newbioideas.com

 

 

CitationBoominathan, L., A Lotus way to lengthen lifespan: The Lotus component Nucinferin-based therapy for life-span extension: Nucinferin, isolated from lotus leaf, may  increase insulin sensitivity, slow down cardiac aging, and increase lifespan, via up-regulation of BubR1 and others genes, 23/August/2018, 2.36 pm,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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