Assigning an unknown function to a known reproductive hormone Follicle-stimulating hormone (FSH) in Longevity: FSH-based therapy for aging-associated diseases and Lifespan extension: FSH increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 8/August/2018, 11.43 pm

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Introduction: What they say

A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and Department of Pharmacology, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia shows that A conserved NAD+ binding pocket that regulates protein-protein interactions during aging.” This research paper was published, in the 24 March 2017 issue of the journal “Science” [One of the best research journals in Science with an I.F of 34+], by Prof. David A. Sinclair, Jun Li and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Assigning an unknown function to a known reproductive hormone Follicle-stimulating hormone (FSH) in Longevity: FSH-based therapy for aging-associated diseases and Lifespan extension: FSH increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene

Price 500


What is known?

Prof. David A. Sinclair’s research team has recently shown that: (a) increased levels of NAD+ (found in non-aged tissues) inhibits the interaction the between DBC1 (deleted in breast cancer 1) and PARP1 [poly(adenosine diphosphate–ribose) polymerase]; and promotes DNA repair; (b) decreased levels of NAD+ (found in aged tissues) promotes the interaction between DBC1 and PARP1 and inhibits DNA repair; (c) aged cells/tissues that are low in NAD+ are radiation-sensitive, cancer-prone and prone to accelerated ageing; and (d) ageing-associated diseases can be reversed by increasing the concentration of NAD+ in ageing tissues, suggesting that ageing-associated diseases, in part, can be reversed by NAD+ supplementation in older animals.


From research findings to therapeutic opportunity:

This study suggests, for the first time, that a reproductive hormone–with detailed mechanistic insights–may play a role in health/lifespan. FSH(Follicle stimulating hormone) is known to play a role in the development of eggs, and follicular/pubertal maturation in females, while in males it plays a role in the development of sperms. 

 FSH, by increasing the expression of its target gene, it may increase the levels of NAMPT and NMN/NAD+. Thereby, it may: (1) increase plasma NMN levels and tissue NAD+ availability; (2) inhibit the interaction between DBC1 and PARP1; (3) augment PARP1’s DNA repair activity; (4) protect against radiation; (5) protect against cancer; and (6) prevent age-associated gene expression pattern and accelerated ageing(fig.1).

Figure1. FSH functions as a longevity-promoting agent. FSH, by increasing NAD+ levels, may suppress aging-associated overall physiological decline, aging-associated diseases and improve health/lifespan

Figure 2. FSH functions as a longevity promoter through induction of NMN/NAD+ and PARP1 activity

Thus, pharmacological formulations encompassing ” FSH inducers or their analogs, either alone or in combination with other drugs,” may be used to suppress age-associated overall physiological decline and improve health/lifespan.[easy_payment currency=”USD”]


 

 

 

 

 

 

Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How FSH  increases the levels of NMN/NAD to inhibit the interaction between DBC1 and PARP1 and to promote DNA repair activity

Amount: $500#

* Research cooperation

For purchase and payment details, you may reach us at info@genomediscovery.org


References:

Citation: Boominathan, L., Assigning an unknown function to a known reproductive hormone Follicle-stimulating hormone (FSH) in Longevity: FSH-based therapy for aging-associated diseases and Lifespan extension: FSH increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 8/August/2018, 11.43 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

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