Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 19/August/2017, 11.23 pm

Revealing the unrevealed function of  the reproductive hormone Relaxin in the heart: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, inhibits DNA damage responses, induces telomerase expression, inhibits telomere shortening, and promotes cardiomyocyte survival after myocardial infarction, via up-regulation of PNUTS, 19/August/2018, 12.35 am
August 18, 2018
Revealing the unrevealed function of  the reproductive hormone Relaxin in triglycerides/cholesterol reduction and in the treatment of Non-alcoholic fatty liver disease (NAFLD) : Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature,  promotes degradation of HMGCR, decreases the levels of triglycerides, free cholesterol, and total cholesterol and prevents the progression of NAFLD, via down-regulation of its target gene, 19/August/2018, 11.45 pm
August 19, 2018
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What they say: 

A study from the Institute of Healthy Ageing, Centre for Diabetes and Endocrinology, Department of Medicine, University College London, London WC1E 6JJ, UK shows that “Ribosomal protein S6 kinase 1 signaling regulates mammalian life span.” This study was published, in the 2 October 2009 issue of the Journal “Science” (I.F: 31.477 ), by Prof Dominic J. Withers, Dr. Selman C, and others.


What we say

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMDreports, for the first time, that: Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene


Research findings to Therapeutic opportunity: 

Estradiol(E2), a steroid female sex hormone, has also been shown to aid in the treatment of a number of other gynecological conditions.  This study suggests, for the first time, that Estradiol(E2), by increasing the expression of its target gene, it may suppress ribosomal protein S6 kinase 1 (p70S6 Kinase) expression. Thereby, it may promote (1) resistance to the bone, immune, and motor dysfunction; (2) insulin sensitivity; and (3) longevity (fig. 1).

Figure 1. Mechanistic insight into how Estradiol(E2) may extend lifespan. Estradiol(E2) inhibits p70 S6 kinase expression and increases the expression of other longevity- promoting genes.

Figure 2. The chemical structure of Estradiol(E2). Estradiol(E2) functions as a longevity promoting agent through down-regulation of p70S6 kinase

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Thus, pharmacological formulations encompassing Estradiol or its analogs,  either alone or in combination with any of the known longevity-promoting compound(s), may be used to extend the lifespan of an individual (fig. 2).

Given the mechanistic basis of how Estradiol may function as a longevity-promoting agent, obstetricians and gynecologists and general practitioners may consider: encouraging their needy patients(post-menopausal women) to take Estradiol or beginning a clinical trial.  


Details of the research findings: 

Idea Proposed/Formulated (with experimental evidence) by:

Dr L Boominathan Ph.D.

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Undisclosed mechanistic Information: How Estradiol decreases the expression of p70 S6 Kinase and promotes mammalian lifespan

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References:

CitationBoominathan, L.,  Estradiol functions as a longevity promoter: Estradiol, a female steroid hormone, inhibits the expression of Ribosomal protein S6 kinase 1 (p70S6 Kinase) and extends mammalian lifespan, via upregulation of its target gene, 19/August/2017, 11.23 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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