Optimal levels of a reproductive hormone FSH(Follicle stimulating hormone) may keep cardiac diseases at bay: FSH-based cardiac rejuvenation therapy: FSH, a gonadotrophin and polypeptide hormone, suppresses tumor suppressor INK4a/p16 expression and inhibits dilated cardiomyopathy, via upregulation of its target gene, 3/August/2018, 1.25 pm

What we say:

Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Optimal levels of a reproductive hormone FSH(Follicle stimulating hormone) may keep cardiac diseases at bay: FSH-based cardiac rejuvenation therapy: FSH, a gonadotrophin and polypeptide hormone, suppresses tumor suppressor INK4a/p16 expression and inhibits dilated cardiomyopathy, via upregulation of its target gene

From the Significance of the study to Public health relevance:

Given that: (1) cardiovascular disease is the leading cause of death worldwide; (2) Dilated cardiomyopathy is the leading cause of Heart failure; (3) the raise  of death rate, due to cardiovascular disease, has increased from 12.3 million in 1990 to 17.3 million in 2013; (4) 13% of cardiovascular disease occur due to  uncontrolled high blood pressure; (5) in India, in 2004, 14.6 lakhs deaths (14% of total deaths) were due to ischemic heart disease; (6) 85% of people over  80 years are susceptible to cardiovascular diseases; (7) the global economic cost spent in the treatment of cardiovascular disease in 2011 was little more than 10 billion US dollars; (8) the death due to cardiovascular disease is higher in low-to-middle income countries compared to developed countries; and (9) an alarming number of people, such as 230 lakhs people, will die from cardiovascular diseases each year by 2030, there is an urgent need to find:  (i) a cure to diseases, as mentioned above, leading to cardiovascular disease; (ii) a way to induce regeneration of adult cardiomyocytes that were lost in Myocardial patients; (iii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug.

From research findings to therapeutic opportunity:  

FSH, by increasing the expression of its target gene, it may increase the expression of oncoprotein BMI-1. And,  thereby, suppress the expression of tumour suppressor and the aging marker INK4a/p16 (figure 1 ).

Figure 1. Mechanistic insight into how FSH vaccine may function as a cardioprotective agent. FSH inhibits dilated cardiomyopathy and heart failure via down-regulation of aging/senescence marker INK4a

Figure 2. The reproductive hormone FSH  may attenuate senescence, and dilated cardiomyopathy through down-regulation of INK4a.

Thereby, it may: (1) inhibit cardiac senescence; (2) increase of regenerative potential in aged tissues; and (3) improve ventricular dimensions and contractility.

Thus, (1) FSH inducers may prevent dilated cardiomyopathy and ageing-associated (or, stress-associated) decline in cardiac function; and (2) FSH inducers, either alone or in combination with other drugs,” may be used to treat dilated cardiomyopathy and heart failure (figure 1).

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by: Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does FSH decrease the expression of INK4a?

Amount: $500#

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References:

Web: http://genomediscovery.org or newbioideas.com

Citation: Boominathan, L., Optimal levels of a reproductive hormone FSH(Follicle stimulating hormone) may keep cardiac diseases at bay: FSH-based cardiac rejuvenation therapy: FSH, a gonadotrophin and polypeptide hormone, suppresses tumor suppressor INK4a/p16 expression and inhibits dilated cardiomyopathy, via upregulation of its target gene, 3/August/2018, 1.25 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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