August

August 6, 2018

Flu vaccine for pain therapy: Influenza A (H1N1)/Flu vaccine-based activation of the PD-1 pathway for Pain therapy:  Influenza A (H1N1)/Flu vaccine increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability, via up-regulation of its target gene, 6/August/2018, 7.40 am

 Introduction: What they say: A recent study, from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for […]
August 4, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as LATS1, SMARCA4, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 8/August/2018, 11.51 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 4, 2018

Assigning an unknown function to a known reproductive hormone Follicle-stimulating hormone (FSH) in Longevity: FSH-based therapy for aging-associated diseases and Lifespan extension: FSH increases NMN/NAD levels, decreases interaction of DBC1 with PARP1, increases PARP1 activity, promotes DNA repair, augments tolerance against radiation, cancer, and aging, via down-regulation of its target gene, 8/August/2018, 11.43 pm

Introduction: What they say A study from Department of Genetics, Paul F. Glenn Center for the Biology of Aging, Harvard Medical School, Boston, MA, USA; and […]
August 4, 2018

Combinatorial therapy for gynecologic cancers: A therapeutic mix encompassing  Macbecin, Temozolomide, EGCG, Salinomycin, Fluvastatin, and Chloroquine (MTESFC) inhibits the expression of HDAC6, acetylates tumor suppressor proteins, activates tumor suppressor function, and stifles the progression of ARID1A-mutated ovarian cancers via up-regulation of its target gene, 4/August/2018, 5.16 pm

Introduction: What they say: A study from Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA shows that “ARID1A-mutated ovarian cancers depend on […]