August

August 29, 2018

Relaxin relieves you of stroke-risk: Relaxin, a protein hormone that facilitates labor and relaxes the uterine musculature, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 29/August/2018, 7.46 am

Introduction: What they say  A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; […]
August 27, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  FBOX11, Sprouty1/2, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/August/2018, 12.17 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 27, 2018

Repurposing an anti-diabetic drug into an anti-cancer drug: Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as  TIMP3, CCM3/KRIT1, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 28/August/2018, 12.09 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 27, 2018

A sere(ne)laxin-way to stay free of cardiac diseases: Serelaxin-based therapy for attenuating pathogenesis-associated with Myocardial infarction: Serelaxin, a recombinant Relaxin-2,  decreases IRF3 (Interferon regulatory transcription factor-3), GM-CSF (Granulocyte-macrophage colony-stimulating factor) and GRK2(G protein-coupled receptor kinase) expression, inhibits undue leucocyte activation and invasion, suppresses recruitment of inflammatory cells, inhibits ventricular dilation, and promotes heart repair and survival, via up-regulation of its target gene, 27/August/2018, 11.25 pm

Introduction: What they say: A recent study from Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA; and Cardiovascular Research Center, Massachusetts General Hospital and […]