August

August 1, 2018

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: Emodin, isolated from Rhubarb and others,  increases the expression of tumor suppressors genes, such as  BigH3, TIPE2, TA-p73, TAp63, p53, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 1/August/2018, 3.21 pm

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
August 1, 2018

Vaccine for lowering cholesterol, and triglycerides levels: Repurposing the CTB-UE vaccine into a cholesterol-lowering vaccine that inhibits Non-alcoholic fatty liver disease (NAFLD): CTB-UE vaccine, which protects against H.Pylori infection, decreases the levels of HMGCR,  triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD, via down regulation of its target gene, 1/August/2018, 3.16 pm

Significance of the study: Given that: (1)  15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to […]
August 1, 2018

Bacillus Calmette Guerin (BCG)/tuberculosis (TB) vaccine aids in the treatment of Deafness: BCG/TB vaccine increases the expression of ATG5 (Autophagy-related 5), prevents aggregation of proteins in inclusion bodies, inhibits hair cell degeneration,  improves hearing loss via upregulation of its target genes, 1/August/2018, 2.10 pm

  What we say: Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Bacillus Calmette Guerin (BCG)/tuberculosis (TB) aids in the treatment of Deafness: BCG/TB vaccine increases the expression […]
August 1, 2018

Reproductive hormone aids in the treatment of blood sugar disease: FSH (Follicle stimulating hormone)-based therapy for DM: FSH increases the expression of IGF1R, INSR, and IRS2, and promotes an insulin-sensitized state, via up-regulation of  its target gene Lin28, 1/August/2018, 10.59 am

Introduction: What they say:   A study from the Stem Cell Transplantation Program, Division of Pediatric Hematology/Oncology, Boston Children’s Hospital and Dana-Farber Cancer Institute, Boston, Massachusetts, USA shows that “The Lin28/let-7 axis […]