TB vaccine for learning/memory/cognitive-enhancement (neither mocking nor joking, but presenting with mindful mechanistic insights, supported by scientific evidences) therapy: TB/BCG vaccine, a tuberculosis vaccine,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target gene, 6/August/2018, 2.08 pm

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Introduction: What they say:

A study from Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA;  Paul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA Neuroscience Graduate Program, Stanford University School of Medicine, Stanford, California 94305, USA; Center for Tissue Regeneration, Repair and Restoration, V.A. Palo Alto Healthcare System, Palo Alto, California 94304, USA shows that “Human umbilical cord plasma proteins revitalize hippocampal function in aged mice. This research paper was published, in the 19 April 2017 issue of the journal “Nature” [One of the best research journals in General sciences with an I.F of 43+], by Prof. Wyss-Coray, Castellano JM and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  TB vaccine for learning/memory/cognitive-enhancement (neither mocking nor joking, but presenting with mindful mechanistic insights, supported by scientific evidences) therapy: TB/BCG vaccine, a tuberculosis vaccine,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target gene


What is known?

Prof.Tony Wyss-Coray’s research team has recently shown that:  (1) human cord plasma treatment promotes cognitive and learning function in aged mice; (2) blood-borne component Tissue inhibitor of metalloproteinases 2 (TIMP2) is enriched in human cord plasma, young mouse plasma, and young mouse hippocampi; (3) TIMP2 increases hippocampal-dependent cognition; and (4) treating brain slices with TIMP2 antibody inhibits long-term potentiation and prevents hippocampal function, suggesting that increasing the expression of TIMP2 in aged individuals may enhance learning and memory.


Research findings to Therapeutic opportunity:

This study suggests, first the first time, a Bacillus Calmette Guerin (BCG)/tuberculosis(TB) vaccine-based therapy, with detailed mechanistic insights, for improved learning, memory, and cognition. BCG vaccine has been found to be useful in the treatment of tuberculosis, for more than 100 years, more recently in the treatment of autoimmune diabetes. However, the mechanism of action remains largely unknown.

TB/BCG vaccine, by increasing the expression of its target genes, it may increase the levels of TIMP2. Thereby, it may: (1) increase the expression of genes that promote learning and memory; (2) augment cognition and learning; (3) improve spatial memory, and (4) promote hippocampal function (fig.1). Thus, TB/BCG vaccine, either alone or in combination with other drugs,” may be used to suppress the age-associated decline of overall physiological hippocampal function;  and improve cognition and memory (fig.2). However, one has to keep in mind, the positive effect of TB/BCG vaccine on memory, learning, and cognition, will be permanent or transient, is not clear at present. Besides, how frequently TB/BCG vaccination is required,  to maintain the optimal level of cognition and memory, in the elderly, is also not clear at present.  To clarify these issues, one has to substantiate the evidence presented here, with more experimental work, plus start a clinical trial. Together, this study suggests, for the first time, an unknown action of the known TB/BCG vaccine in learning/memory/cognitive-enhancement (fig.2).

Figure1. Mechanistic insights into how  TB/BCG vaccine functions as a positive regulator of learning and memory. TB/BCG vaccine, by increasing the expression of TIMP2, it increases learning and memory in aged individuals

Figure 2. Repurposing the TB/BCG vaccine into a learning, memory, & cognitive augmentation vaccine

 

 

 

 

 

 

 

 

 

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Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Undisclosed mechanistic information: How does TB/BCG vaccine increase the levels of TIMP2?

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References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L.,  TB vaccine for learning/memory/cognitive-enhancement (neither mocking nor joking, but presenting with mindful mechanistic insights, supported by scientific evidence): TB/BCG vaccine, a tuberculosis vaccine,  increases Tissue inhibitor of metalloproteinases 2 (TIMP2) levels, improves cognition, and decreases age-associated decline in memory and learning, via down-regulation of its target gene, 6/August/2018, 2.07 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

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