Significance of the study:
Given that: (1) 15-30% of Western populations suffer from Non-alcoholic fatty liver disease (NAFLD), while 6-25% of Asian populations suffer from it; (2) 75 to 100 million people in the US succumb to this disease; (3) obesity and type 2 diabetes are risk factor for the development of NAFLD; and (4) the global economic cost spent for NAFLD is enormous, there is an urgent need to find: (i) a way to decrease cholesterol deposition in liver; (ii) a cheaper alternative to the existing expensive drugs; (iii) a side-effect-free natural product-based drug; and (iv) a way to cure, not just treat, NAFLD.
Research findings to Therapeutic opportunity:
This study suggests, first the first time, Helicobacter Pyroli vaccine CTB-UE-based therapy, with detailed mechanistic insights, for lowering cholesterol and triglyceride levels.
CTB-UE vaccine, which contains mucosal adjuvant cholera toxin B subunit (CTB) and five cell epitopes from the H. pylori urease subunits,, has been shown to be effective in controlling infections caused by H. pylori. However, the mechanism of action remains largely unknown.
CTB-UE vaccine, by increasing the expression of its target gene, it may suppress the expression of HMGCR (Fig.1). Thereby, it may: (1) decrease Triglycerides, free cholesterol and total cholesterol levels; (2) attenuate lipid deposition in the liver; and (3) inhibit progression to NAFLD (Fig. 1). Thus, CTB-UE vaccine, either alone or in combination with other drugs, may be used to treat NAFLD.
Details of the research findings:
Idea Proposed/Formulated (with experimental evidence) by:
Dr L Boominathan Ph.D.
Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/
Undisclosed mechanistic information: How does CTB-UE vaccine decrease the expression of HMGCR and prevent NAFLD?
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Citation: Boominathan, L.,Vaccine for lowering cholesterol, and triglycerides levels: Repurposing the CTB-UE vaccine into a cholesterol-lowering vaccine that inhibits Non-alcoholic fatty liver disease (NAFLD): CTB-UE vaccine, which protects against H.Pylori infection, decreases the levels of HMGCR, triglycerides, free cholesterol, and total cholesterol and prevents the progression of Non-alcoholic fatty liver disease (NAFLD, via down-regulation of its target gene, 1/August/2018, 3.15 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org
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