September 3, 2018

Act(os) against cancer: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as CADM1, RECK,   p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 4/September/2018, 1.50 am

From Significance of the study to Public health relevance:  Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different […]
September 3, 2018

Regular dark chocolate consumption may insulate your heart against cardiac dysfunction: Chocolate-derived compound theobromine-based adjunct therapy for cardiac hypertrophy and fibrosis: Theobromine,  one of the main components of dark chocolate, decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 4/September/2018, 1.42 am

Introduction: What they say:   A recent study from the Institute of Pharmacology and Toxicology, Technical University Munich (TUM), 80802, Munich, Germany; DZHK (German Center for Cardiovascular […]
September 3, 2018

Chocolate your way to stay free of pulmonary arterial hypertension (PAH): Monomeric cocoa catechins, one of the components of dark chocolates, inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 3/August/2018, 11.36 pm

What they say:  A study from the University of California, La Jolla, California, USA shows that “Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number […]