September 26, 2018

Mechanistic insights into how analgesic agent Methadone attenuates pain: Methadone(trade name: Dolphine & Methadose), an analgesic drug used mainly in post-operative pain relief, increases the expression of PD-L1, attenuates acute and chronic pain, and suppresses mechanical and thermal hypersensitivity and inhibits nociceptive neuron excitability via up-regulation of its target gene, 27/September/2018, 12.43 am

Introduction:What they say: A recent study from Institute of Neurobiology, Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Collaborative Innovation Center for Brain […]
September 26, 2018

Repurposing the lipid-lowering statin Simvastatin as a longevity-promoting agent: Statin-based combinatorial therapy for Lifespan extension: A therapeutic mix encompassing Simvastatin, Ursolic acid, Maresin, DIM, Ursolic acid  Lutein, Maresin, Cholecalciferol, Catalpol, Isoliquiritigenin (SUMDULMCCI) activates autophagy, promotes leanness, increases insulin sensitivity, improves motor function, alleviates ageing feature and extends lifespan via upregulation of its target gene ATG5 (Autophagy-related 5), 26/September/2018, 11.41 pm

Introduction: What they say A study from the Global Research Laboratory, Seoul National University, Korea shows that “Overexpression of Atg5 in mice activates autophagy and extends lifespan.” This study was […]
September 26, 2018

Mechanistic insights into how a statin-based drug stifles anxiety and depression: Simvastatin, a lipid-lowering agent, decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 26/September/2018, 11.22 pm

Introduction: What they say:  A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department […]