A derivative of sulfamoylated Estrone comes to the rescue of anxiety and depression: 2-Ethylestrone-3-O-sulfamate (2EtEMATE) decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 11.00 pm

Probiotics as anti-infective agents:  Probiotics-based adjunct therapy for viral and bacterial infections: Probiotic Lactobacillus Rhamnosus inhibits Hepatitis-B/C, Dengue, Zika, Ebola, HIV-1, Mtb, Malaria, CMV, Influenza H1NI1,  respiratory syncytial,  Sindbis, and SFV viruses by increasing the Levels of the antiviral Proteins IFITM3, & Interferon-stimulated gene, 21/September/2018, 10.29 pm
September 21, 2018
A cup of Probiotic a day keeps stroke-risk at bay: Probiotic lactobacillus brevis attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 23/September/2018, 1.22 pm
September 23, 2018
Show all

Introduction: What they say: 

A study from Department of Molecular Biology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA; and Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA shows that “Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice.” This research paper was published, in the May 2017 issue of the journal “Nature communications” [One of the best research journals in Metabolism with an I.Fs of ], by Prof.Hochedlinger K, Ryan M. Walsh and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  A derivative of sulfamoylated Estrone comes to the rescue of anxiety and depression: 2-Ethylestrone-3-O-sulfamate (2EtEMATE) decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene


From the significance of the study to Public health relevance:

Given that: (1) one in three suffer from anxiety-related disorders worldwide; (2) nearly 12% of world population suffer from anxiety-related disorders in any given year; (3) 5-30% of people suffer from anxiety at some point in their lives; (4) 40 million adults in the US suffer from anxiety disorders; (5) nearly $42 billion a year spent in the US to treat anxiety disorders; (6) anxiety and depression are associated with higher rate of morbidity; (7) the percentage of people who suffer from anxiety is more from developed countries than from developing countries, while the opposite is true with depression; and (8) the global economic cost spent in the treatment of anxiety and depression occupies the significant portion of health care bill, there is an urgent need to find: (i) a way to cure  long term anxiety and depression that are leading to a number of serious health complications; (ii) a way to induce resilience to anxiety and depression; (iii) a cheaper alternative to the existing expensive drugs; and (iv) a side-effect-free Natural product-based drug that not only alleviates, but also cures anxiety and depression.


What is known?

Mutations in PHF8, a histone demethylase, has been shown to result in cognitive defects and cleft lip/palate. However, its role in other physiological processes remains to be determined.

Prof.Hochedlinger Konrad’s research team has recently shown that knocking out PHF8/JMJD1.2 in mice results in: (1) no cognitive impairment; (2) up-regulation of serotonin receptors Htr1a and Htr2; (3) normalization of Serotonin signalling; and (4) resistance to stress-induced anxiety- and depression-like behaviour, suggesting that inhibiting the expression of PHF8 may aid in the treatment of anxiety and depression.


From research findings to Therapeutic opportunity:

This study suggests, for the first time, that 2-ethylestrone3-O-sulfamate (2EtEMATE) may attenuate anxiety and depression.

2-ethylestrone-3-O-sulfamate (2EtEMATE), by increasing the expression of its target gene, it may decrease the expression of PHF8. Thereby, it may: (1) increase the expression of genes involved in serotonin signaling such as Htr1a and Htr2a; (2) normalize serotonin signaling; (3) promote resistance to stress-induced anxiety, and (4) heighten resistance to stress-induced depression-like behavior. Thus, pharmacological formulations encompassing “2-EtEMATE or its analogs, either alone or in combination with other drugs, may be used to treat anxiety and depression; and promote resistance to depression- and anxiety-like behaviors (fig 1).[easy_payment currency=”USD”]

Given the mechanistic basis of how 2-EtEMATE may function as an anti-depressive agent,  physicians and psychologists may consider: treating their needy patients with 2-EtEMATE or beginning a clinical trial.  

Figure1. Mechanistic insights into how 2-EtEMATE decreases PHF8 levels, increases serotonin receptors Htr1a and Htr2a levels and promotes resistance to depression-like and anxiety-like behaviors

Figure 2. The chemical structure of 2-EtEMATE. 2-EtEMATE functions as an anti-depressive agent through up-regulation of its target genes

 

 

 

 

 

 

 

 

 


Details of the research findings:

Idea Proposed/Formulated (with experimental evidence) by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $ 500#

Undisclosed mechanistic information: How 2-ethylestrone-3-O-sulfamate (2EtEMATE) decreases PHF8 levels, increases serotonin receptors Htr1a and Htr2a levels and promotes resistance to stress-induced anxiety and depression.

# Research cooperation

For purchase and payment details, you may reach us at admin@genomediscovery.org


References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., A derivative of sulfamoylated Estrone comes to the rescue of anxiety and depression: 2-Ethylestrone-3-O-sulfamate (2EtEMATE) decreases PHF8 levels, increases the expression of serotonin receptors Htr1a and Htr2a, and promotes resistance to stress-induced -anxiety and -depression, via down-regulation of its target gene, 21/September/2018, 11.00 pm, Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, kindly drop us a line at admin@genomediscovery.orgbme

Comments are closed.