Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  PTPN14, Rb, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 5/September/2018, 11.07 am

Consuming one dark chocolate bar a day strengthen your heart: Dark chocolate-based therapy for cardiomyocyte proliferation and heart regeneration: Dark chocolate decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 5/September/2018, 10.30am
September 5, 2018
Act(os) against cancer: Pioglitazone (trade name: Actos), an anti-diabetic drug, increases the expression of tumor suppressors genes, such as PIAS3, IGFBP3, p53,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 5/September/2018, 11.14 am
September 5, 2018
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Teacher’s day special

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We wish everyone a happy Teacher’s day. On this special occasion, we are happy to announce that ideas posted today (05/September/2017) will be available to the use of Scientists/Professors/Physicians/Researchers for free. So, there will be no terms and conditions, for the ideas posted today (05/September/2018). Each idea posted will be served first-come, first served basis.

Write to info@genomediscovery.org for more details.

Dr L Boominathan PhD

CEO & CSO, GBMD

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From Significance of the study to Public health relevance

Given that: (1) cancer suppressor p53 is mutated in more than 50% of human cancers of different tissue origin; (2) p53 pathway is altered in about 80% of tumors.; (3) our understanding is incomplete in terms of molecular targets and the oncogenic/malignant pathways involved in mutant p53-overexpressing tumors; (4) cancer causes the highest economic loss compared to all the known causes of death worldwide; and (5) cancer causes the considerable economic loss worldwide, there is an urgent need to find: (i) a cheaper alternative to the existing expensive drugs; (ii) a side-effect-free natural product-based drug; and (iii) a way to effectively treat and stall metastatic progression and relapse of mutant p53-overexpressing human cancers.


From therapeutic strategy to Research Findings:

(i) Therapeutic strategy: 

This study suggests a therapeutic strategy for stalling the progression of p53-deficient/deleted or mutant-p53 expressing metastatic cancers. By activating tumor suppressor p53’s unmutated “homologous protein such as TAp73/p63” in p53-deficient or mutant-p53 expressing metastatic cancer cells, one can stall their progression.

(ii) Research findings:  

PCGF2/Mel-18 has been shown to function as a tumor suppressor in a number of cancers. However, the mechanism of action remains largely unknown.

Figure 1. Mechanistic insight into how  PCGF2/Mel-18 functions as an anticancer/antimetastatic agent in mutant p53-expressing tumors.  PCGF2/Mel-18,  by activating tumor/metastasis suppressor genes, such as PTPN14, Rb1, p53, TAp63, TAp73, INK4a/ARF and others, in metastatic tumors, it may inhibit the progression of mutant-p53 expressing human cancers.

Figure 2. PCGF2/Mel-18 functions as an anti-tumor/metastatic agent through induction of tumor/metastatic suppressor genes, such as  PTPN14, Rb1,  p53, TAp63, TAp73, and INK4aThis study suggests that PCGF2/Mel-18 may function as an anti-cancer/metastasis agent by increasing the expression a number of tumor/metastasis suppressor genes.

PCGF2/Mel-18, by increasing the expression of its target gene, it may increase the expression of tumor/metastasis suppressors genes, such as PTPN14, Rb1, TA-p73, TAp63, p53, INK4a/ARF and others. Thereby, it may inhibit the migration and invasion of metastatic cancer cells expressing mutant-p53 (figure1).

 


Therapeutic opportunity:

Given the ability of PCGF2/Mel-18 to induce the expression of a number of tumor/metastasis suppressor genes, its activators or inducers may be used, either alone or in combination with other anticancer drugs, to inhibit the progression of p53-mutated invasive metastatic tumors. Taken together, this study suggests, for the first time, that oncologists may consider treating terminally ill metastatic cancer patients with PCGF2/Mel-18 inducers, as it may stall the progression of advanced metastatic cancers. (figure 2).


Details of the research findings

Idea Proposed/Formulated by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $300#

Undisclosed mechanistic information: How PCGF2/Mel-18 increases the expression of tumor suppressor genes, such as PTPN14, Rb1, p53, TAp63, TAp73, INK4a/ARF and others,  in mutant p53 expressing cancer cells?

For purchase and payment details, you may reach us at admin@genomediscovery.org

#Research cooperation

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References:

Web: http://genomediscovery.org or http://newbioideas.com

Citation: Boominathan, L., Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  PTPN14, Rb, p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 5/September/2018, 11.07 am, Genome-2-Biomedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at admin@genomediscovery.org

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