Chocolate your way to stay free of pulmonary arterial hypertension (PAH): Monomeric cocoa catechins, one of the components of dark chocolates, inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 3/August/2018, 11.36 pm

Awakening the sleeping/cancer-protecting angels in mutant p53-expressing human tumors: PCGF2/Mel-18 increases the expression of tumor suppressors genes, such as  KISS1, TCF21,  p53, TAp63, TAp73, INK4a/ARF, and others, induces regression of p53-mutated human tumors, via down-regulation of its target gene, 3/September/2018, 12.23 am
September 2, 2018
Regular dark chocolate consumption may insulate your heart against cardiac dysfunction: Chocolate-derived compound theobromine-based adjunct therapy for cardiac hypertrophy and fibrosis: Theobromine,  one of the main components of dark chocolate, decreases Mir-29 expression, activates Wnt- signaling and its components GSK3B, ICAT/CTNNBIP1, HBP1, and GLIS2, attenuates pathologic hypertrophy, inhibits fibrosis of the heart tissue, and improves cardiac function via upregulation of its target gene, 4/September/2018, 1.42 am
September 3, 2018
Show all

What they say: 

A study from the University of California, La Jolla, California, USA shows that Notch3 signaling promotes the development of pulmonary arterial hypertension.” This study was published, in the 15 November  2009 issue of the journal “Nature Medicine”[the number 1 journal in General Medicine with an I.F of 28.054],  by Prof. Thistlethwaite PA, Li X and others.


What we say: 

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that: Chocolate your way to stay free of pulmonary arterial hypertension (PAH): Monomeric cocoa catechins, one of the components of dark chocolates, inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3


The significance of the study:  

This study suggests, for the first time, that Monomeric cocoa catechinby increasing the expression of its target gene, it may decrease the expression of Notch3 and its target gene Hes-5 (Fig.1). Thereby, it may inhibit and promote, respectively, proliferation and differentiation of smooth muscle cells. And, thereby, prevent pulmonary hypertension (Figure 1).  Thus, pharmacological formulations encompassing “Monomeric cocoa catechin or its analogs, either alone or in combination with other drugs,” may be used to treat pulmonary arterial hypertension (PAH) (Fig. 2). Together, by treating pulmonary hypertensive patients with monomeric cocoa catechinone may prevent pulmonary arterial hypertension

Figure 1. Mechanistic insights into how monomeric cocoa catechin inhibits the development of pulmonary hypertension.

Figure 2. The chemical structure of Monomeric cocoa catechins.

 

 

 

 

 

 

 

 


Details of the research findings: 

Idea Proposed/Formulated byDr L Boominathan Ph.D.

Undisclosed mechanistic information: How  Monomeric cocoa catechin  decreases the expression of Notch3 and its target gene

Amount: $500#

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References: 

Web: http://genomediscovery.org or http://newbioideas.com/

CitationBoominathan, L.,   Chocolate your way to stay free of pulmonary arterial hypertension (PAH): Monomeric cocoa catechins, one of the components of dark chocolates, inhibits the development of pulmonary arterial hypertension via down-regulation of its target gene Notch3, 3/August/2018, 11.36 pm,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite us, drop us a line at info@genomediscovery.org

Comments are closed.