Eating one chocolate bar a day keeps stroke at bay: Chocolate-based therapy for Stroke: Theobromine, one of the components of dark chocolate, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 5/September/2018, 9.24 am

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Consuming one dark chocolate bar a day strengthen your heart: Dark chocolate-based therapy for cardiomyocyte proliferation and heart regeneration: Dark chocolate decreases tumor suppressor Mir-128 and cyclin-dependent kinase inhibitor p27 expression, increases SUZ12 expression, increases Cyclin E and CDK2 expression, promotes proliferation/re-entry of postnatal/adult cardiomyocytes, attenuates fibrosis, ameliorates cardiac dysfunction, and promotes heart repair in response to myocardial infarction, via up-regulation of its target gene, 5/September/2018, 10.30am
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Teacher’s day special

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We wish everyone a happy Teacher’s day. On this special occasion, we are happy to announce that ideas posted today (05/September/2017) will be available to the use of Scientists/Professors/Physicians/Researchers for free. So, there will be no terms and conditions, for the ideas posted today (05/September/2018). Each idea posted will be served first-come, first served basis.

Write to info@genomediscovery.org for more details.

Dr L Boominathan PhD

CEO & CSO, GBMD

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Introduction: What they say

A recent study from Research Center for Neurobiology and Department of Neurobiology, Xuzhou Medical College, 209 Tongshan Road, Xuzhou, Jiangsu 221004, PR China; and School of Public Health, Xuzhou Medical College, PR China shows that “HO-1 attenuates hippocampal neurons injury via the activation of BDNF-TrkB-PI3K/Akt signaling pathway in stroke. This study was published, in the July 2, 2014, issue of the journal Brain Research,  by Prof  Dong, Qi, and others.

Another study from the Department of Pharmacology, Second Military Medical University, Shanghai, China; Department of Science and Education, Shandong Provincial Hospital affiliated to Shandong University, Jinan, China; and Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China (C.-Y.M.) shows that “Regenerative Neurogenesis After Ischemic Stroke Promoted by Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide Cascade” This study was published, in the June 9 2015 issue of the journal Stroke,  by Prof  Miao CY, Zhao Y, and others.


What we say:

On the foundation of this interesting finding, Dr L Boominathan PhD, Director-cum-chief Scientist of GBMD, reports that:  Eating one chocolate bar a day keeps stroke at bay: Chocolate-based therapy for Stroke: Theobromine, one of the components of dark chocolate, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT


From research findings to therapeutic opportunity: 

Figure 1. Mechanistic insights into how Theobromine protects against stroke. Theobromine protects against stroke via upregulation of its target gene BDNF (Brain-derived growth factor) and NAMPT

Figure 2. Theobromine prevents stroke through induction of Brain-derived growth factor (BDNF) and NAMPT.

Figure 3. The dark chocolate component Theobromine as a stroke medicine.

 

 

 

 

 

 

 

 

 

This study suggests, for the first time,  that Theobromine, by increasing the expression of its target genes, it may: (1) increase the expression of BDNF and NAMPT (Nicotinamide Phosphoribosyltransferase-Nicotinamide Adenine Dinucleotide); (2) augment neuronal–BDNF-TrkB-PI3K/Akt–survival pathway; (3) increase Sirtuins expression; (4) enhance neural stem cells; (5) promote neural functional recovery; (6) attenuate cerebral /Ischemia-reperfusion injury; (7) inhibit neuronal apoptosis; (8) improve learning and memory; and (9) attenuate neurological deficits (Figs.1-2).  [easy_payment currency=”USD”] 

Together, this study suggests, for the first time, that Theobromine may alleviate stroke, and other neurodegenerative diseases (such as multiple sclerosis, cerebral ataxia etc.), promote brain repair and extend the lifespan of an individual. Thus, pharmacological formulations encompassing “Theobromine or its analogs, either alone or in combination with other drugs,” may be used to treat stroke and other neurological deficits.


Details of the idea posted: 

Idea Proposed/Formulated by Dr L Boominathan Ph.D.

Terms & Conditions apply http://genomediscovery.org/registration/terms-and-conditions/

Amount: $500#

Undisclosed mechanistic information: How Theobromine increases the expression of BDNF and NAMPT and attenuates stroke

For purchase and payment details, you may reach us at info@genomediscovery.org

# Research cooperation


References:  

Citation: Boominathan, L., Eating one chocolate bar a day keeps stroke at bay: Chocolate-based therapy for Stroke: Theobromine, one of the components of dark chocolate, attenuates hippocampal neurons injury, augments regenerative neurogenesis after Ischemic Stroke, and ameliorates stroke damage and neurological deficits, via up-regulation of its target genes BDNF and NAMPT, 5/September/2018, 9.24 am,  Genome-2-BioMedicine Discovery center (GBMD), http://genomediscovery.org

Courtesy: When you cite drop us a line at info@genomediscovery.org

Web: http://genomediscovery.org or http://newbioideas.com

 

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